COMPARISON OF CYTHOCROME P450 FAMILY 2 SUBFAMILY A POLYPEPTYDE 6 (CYP2A6) GENE POLYMORPHISM PROPORTION ON EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE
Keywords:Nasopharyngeal carcinoma, Balinese, polymorphism, CYP2A6 gene
Nasopharyngeal carcinoma (NPC) is a malignancy derived from epithelial cells lining the nasopharynx. The etiology of nasopharyngeal carcinoma is multifactorial. One of the risk factors is CYP2A6 gene polymorphism which causes nitrosamines are not metabolized, leading to DNA change that could trigger cancer.
The purpose of this study is to know the association of CYP2A6 gene polymorphism and clinical stage of undifferentiated type of NPC
Material and Method
This is a cross sectional analytic study. The sample in this study were 80 nasopharyngeal carcinoma patients whose treated in ENT-HN department of Sanglah General Hospital between 2017 - 2018. The collected data consist of subject’s characteristic and CYP2A6 gene polymorphisms identified by the PCR-RFLP technique.
The probability of CYP2A6 gene polymorphism in the undifferentiated type of NPC in the Balinese tribe is 3.125 times greater in advanced stage than early stage. Based on multivariate analysis, there was a statistically significant association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese with p value = 0,0048 (p < 0,05).
There is association between CYP2A6 gene polymorphism and clinical stage of undifferentiated type NPC in Balinese tribe.
Adham, M., Kurniawan, A.N., Muhtadi, A.I., Roezin, A., Hermani, B., Gondhowiadjo, S., dkk. 2012. Nasopharyngeal carcinoma in indonesia. Chinese Journal of Cancer. 31(4) : 185–96.
William, I.W. 2012. Nasopharyngeal Cancer. Bailey Head and Surgery Otolaryngology. 4(4) : 213–224.
Pelkonen, O., Rautio, A., Raunio, H., Pasanen, M.2009. CYP2A6 : a human coumarin 7-hydroxylase. Toxicology, 144 : 139–147.
Chen, M., Mai, H., Sun, R., Guo, X,. Zhao, Hua, Y.. 2013. Clinical Finding and Imaging features of Nasopharyngeal Carcinoma with Postradiation Nasopharyngeal Necrosis. J Chin Anti-Ca Associa.32 : 533–538.
Faiza, S., Rahman, S., Asri, A. 2015. Karakteristik klinis dan patologis karsinoma nasofaring di bagian THT-KL Dr M Djamil Padang. Jurnal Kesehatan Andalas. 5 (1) : 90 - 95.
Rao, Y., Hoffman, E., Zia, M., Bodin, L., Zeman, M., Sellers, E.,dkk. 2008. Duplications and Defects in the CYP2A6 Gene : Identification , Genotyping , and In Vivo Effects on Smoking. Mol Pharmacol.58(4) : 747–755.
Saleh, M.I. 2010. Penentuan genotip gen CYP2A6 sebagai biomarker keberhasilan terapi obat yang dimetabolisme melalui enzim CYP2A6. Universitas Sriwijaya. Tidak dipublikasikan
Savitri, B. 2015. Hubungan Polimorfisme Gen CYP2A6*4c Dengan Karsinoma Nasofaring Di Rumah Sakit Dr. Mohammad Hoesin Palembang Periode 2013-2014.
Tiwawech, D., Srivatanakul, P., Karalak, A., Ishida, T. 2006. Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma. Cancer Letter. 241: 135–141.
Wijaya, Hendy. 2011. Gen CYP2A6 meningkatkan risiko ketergantungan fisik perokok terhadap nikotin. Thesis Universitas Udayana, Bali
Ren, Liua, W.S., Qina, H.D., Xua, Y.F., Yua, D.D. 2017. Effect of family history of cancers and environmental factors on risk of nasopharyngeal carcinoma in Guangdong. Cancer Epidemiology Biomarkers and Prevention, 34(4) : 201-207.
American joint committee on cancer. 2018. AJCC cancer stagging form supplemen (8th ed). American College of Surgeon. Chichago ; 1 - 520
Adhikari, A., Madhusnata. 2015. Association of Cytochrome P450 with Cancer Induced . American Journal of Medicine. 1(1) : 1–14.
Tang, K., Li, X., Xing, Q., Li, W., Feng, G., He, L.,dkk. 2010. Genetic polymorphism analysis of cytochrome P4502E1 (CYP2E1) in Chinese Han populations from four different geographic areas of Mainland China. Genomics. 95:224-229.
Akrodou, Y. 2015. CYP2A6 Polymorphisms May Strengthen Individualized. Hindawi Publishing Corporation Scientific.1: 1–7.
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