CORRELATION OF TNF-Α EXPRESSION TO CLINICAL STADIUM IN NASOPHARYNGEAL CARCINOMA

Authors

  • Riko Susilo Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Farhat Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Rizalina A Asnir Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Ashri Yudhistira Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Elvita Rahmi Daulay Department of Radiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
  • Jessy Chrestella Department of Anatomic Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia

DOI:

https://doi.org/10.32734/ijnpc.v2i01.3503

Keywords:

Nasopharyngeal carcinoma, TNF-α, overexpression

Abstract

Introduction:

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia with over 13.000 new cases reported yearly, especially in the male. The TNF-α serum is reported as a new biomarker to predict bone invasion, post-therapy distant metastasis, and poor life sustainability in NPC.

Objective:

To identify the expression of TNF-α in regards to the clinical stage of NPC.

Material and methods:

This is an analytic study with 126 NPC samples of patients in Haji Adam Malik General Hospital.

Results:

NPC mostly found in age group 41-60 years (57.1%), male (71.4%),non-keratinizing SCC (79.4%), and stage IV group (54.8%). In immunohistochemistry evaluation, most of TNF-α overexpressed in non-keratinizing SCC(68.0%), T3-T4 (50.8%), N2-N3 (62.7%) and clinical stage III-IV (69.9%). Spearman's test for categorical correlation yield a p-value of <0,001.

Conclusion:

There is a significant correlation between TNF-α expression and the stage of NPC.

References

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Published

2020-03-18

How to Cite

1.
Susilo R, Farhat, Asnir RA, Yudhistira A, Daulay ER, Chrestella J. CORRELATION OF TNF-Α EXPRESSION TO CLINICAL STADIUM IN NASOPHARYNGEAL CARCINOMA. IJNPC [Internet]. 2020Mar.18 [cited 2020May27];2(01):04-6. Available from: https://talenta.usu.ac.id/IJNPC/article/view/3503