Chemotherapy Management of Nasopharyngeal Carcinoma Patient in General Hospital Haji Adam Malik Medan : A Case Report


  • Saurma Otri Sonya Simanjuntak Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Farhat Farhat Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Elvita Rahmi Daulay Departement of Radiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia



Nasopharyngeal carcinoma, chemotherapy, radiotherapy



Nasopharyngeal carcinoma (NPC) is in the fourth place according to the most most common malignancies in Indonesians. Three types of nasopharyngeal carcinoma are squamous cell, non-keratinizing, and undifferentiated carcinoma.

Case report:

A 51-year-old man came to the ENT-Head and Neck Surgery Outpatient clinic of General Hospital Haji Adam Malik Medan on November 2, 2020 with main complaint of lump on the neck and nasal congestion. The patient underwent a contrast-enhanced nasopharyngeal MSCT scan with the result: T2N0M0. The histopathology results: Non-Keratinizing Squamous Cell Carcinoma. The patient was given 70 gy of Chemoradiation (CRT) followed by adjuvant chemotherapy with Cisplatin + 5 Fu. 


There was no visible mass on the nasopharynx after using this combination therapy


Download data is not yet available.


Brennan B. Nasopharyngeal carcinoma. Orphanet journal of rare Diseases. 2006 Dec;1(1):1-5. DOI:

Weber GF. Molecular mechanisms of cancer. Springer Science & Business Media; 2007 Sep 12.

Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, Tan IB, Middeldorp JM. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chinese journal of cancer. 2012 Apr;31(4):185. DOI:

Zheng CX, Yan L, Nilsson B, Eklund G, Drettner B. Epstein-Barr virus infection, salted fish and nasopharyngeal carcinoma: A case-control study in southern. Acta oncologica. 1994 Jan 1;33(8):867-72. DOI:

Curado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M, Boyle P. Cancer incidence in five continents, Volume IX. IARC Press, International Agency for Research on Cancer; 2007.

Anghel I, Anghel AG, Dumitru M, Soreanu CC. Nasopharyngeal carcinoma–analysis of risk factors and immunological markers. Chirurgia (Bucur). 2012 Sep 1;107(5):640-5.

Wee J, Ha TC, Loong S, Qian CN. Is nasopharyngeal cancer really a” Cantonese cancer”? Chin J Cancer 2010; 29: 517-526

Lam KO, Lee AW, Choi CW, Sze HC, Zietman AL, Hopkins KI, Rosenblatt E. Global pattern of nasopharyngeal cancer: correlation of outcome with access to radiation therapy. International Journal of Radiation Oncology Biology Physics. 2016 Apr 1;94(5):1106-12. DOI:

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90

Su CY, Lui CC. Perineural invasion of the trigeminal nerve in patients with nasopharyngeal carcinoma: Imaging and clinical correlations. Cancer: Interdisciplinary International Journal of the American Cancer Society. 1996 Nov 15;78(10):2063-9. DOI:<2063::AID-CNCR5>3.0.CO;2-P

Jayalie VF, Paramitha MS, Jessica J, Liu CA, Ramadianto AS, Trimartani T, Adham M. Profile of Nasopharyngeal Carcinoma in Dr. Cipto Mangunkusumo National Hospital, 2010. eJournal Kedokteran Indonesia. 2017 Jan 14:156-62. DOI: https://doi/org/10.23886/ejki.4.7110.156-62

Pettaway CA, Srigley JR, Brookland RK. AJCC Cancer Staging Manual. 8th edNew York: Springer-Verlag. 2017.

Chan AT, Grégoire V, Lefebvre JL, Licitra L, Hui EP, Leung SF, Felip E. Nasopharyngeal cancer: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment andfollow-up. Annals of oncology. 2012;23:vii83-5. DOI:

Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. Journal of the National Cancer Institute. 2011 Dec 7;103(23):1761-70. DOI:

Al-Amro A, Al-Rajhi N, Khafaga Y, Memon M, Al-Hebshi A, El-Enbabi A, El-Husseiny G, Radawi A, Belal A, Allam A, El-Sebaie M. Neoadjuvant chemotherapy followed by concurrent chemo-radiation therapy in locally advanced nasopharyngeal carcinoma. International Journal of Radiation Oncology Biology Physics. 2005 Jun 1;62(2):508-13. DOI:

Paiar F, Di Cataldo V, Zei G, Pasquetti EM, Cecchini S, Meattini I, Mangoni M, Agresti B, Iermano C, Bonomo P, Biti G. Role of chemotherapy in nasopharyngeal carcinoma. Oncology reviews. 2012 Mar 5;6(1). DOI:

Wang K, Dong J, He S, Wang X, Jiang C, Hu P, Guo J, Cai X, Wang X. Comparison of weekly and triweekly cisplatin regimens during concurrent chemoradiotherapy for nasopharyngeal carcinoma. BMC cancer. 2019 Dec;19(1):1-9. DOI:

Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, Lu TX, Min HQ. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials. Journal of clinical oncology. 2005 Feb 20;23(6):1118-24.

Chen L, Hu CS, Chen XZ, Hu GQ, Cheng ZB, Sun Y, Li WX, Chen YY, Xie FY, Liang SB, Chen Y. Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. The lancet oncology. 2012 Feb 1;13(2):163-71. DOI:



How to Cite

Simanjuntak SOS, Farhat F, Daulay ER. Chemotherapy Management of Nasopharyngeal Carcinoma Patient in General Hospital Haji Adam Malik Medan : A Case Report. IJNPC [Internet]. 2021Jun.20 [cited 2022Aug.15];3(02):36-7. Available from: