• Felicia Melani Triastuti Center of Excellence Nasopharyngeal Carcinoma, Universitas Sumatera Utara, Indonesia Department of Otorhinolaryngology Head and Neck Medical Faculty of University of Sumatera Utara/H. Adam Malik Medan General Hospital
  • Rizalina A. Asnir Center of Excellence Nasopharyngeal Carcinoma, Universitas Sumatera Utara, Indonesia Department of Otorhinolaryngology Head and Neck Medical Faculty of North Sumatera University/H. Adam Malik Medan General Hospital
  • Ashri Yudhistira Center of Excellence Nasopharyngeal Carcinoma, Universitas Sumatera Utara, Indonesia Department of Otorhinolaryngology Head and Neck Medical Faculty of North Sumatera University/H. Adam Malik Medan General Hospital
  • Sutoyo Eliandy Pathological Anatomy Unit Installation H. Adam Malik Medan General Hospital



Nasopharyngeal carcinoma, E-cadherin, nohistochemistry


Background: Nasopharyngeal carcinoma (NPC) has a high incidence rate in southern China and Southeast Asia and a high rate of metastasis in head and neck cancer. NPC is a squamous cell carcinoma that grows from the surface of the lateral wall of the nasopharynx. E-cadherin is known as a tumor suppressor protein and the loss of this expression in tumor cells is related to epithelial-mesenchymal transition that occurs during tumor development and metastasis.

Objective:To determine the relationship between E-cadherin expression and clinical stage in patients with nasopharyngeal carcinoma.

Methods: An analytical study with a cross-sectional study design, the number of samples was 30 patients with NPC who underwent immunohistochemical examination on KNF paraffin block.

Result: Overexpression of E-cadherin was found in T1 and T2 of 15 subjects (100%). The overexpression of E-cadherin was found in lymph node N2 and N3 of 19 subjects (95%). The overexpression of E-cadherin was found in the histopathological type of Non-Keratinizing Squamous Cell Carcinoma of 24 subjects (96%). The overexpression of E-cadherin was found at an advanced stage of 26 subjects (100%).

Conclusion: No significant association was found between E-cadherin expression and tumor size (p = 1,000), lymph node metastasis (p = 1,000), histopathological type (p = 1,000) and tumor stage (p = 0.133).


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How to Cite

Triastuti FM, Asnir RA, Yudhistira A, Eliandy S. ASSOCIATION OF E-CADHERIN EXPRESSION TO CLINICAL STAGE OF NASOPHARYNGEAL CARCINOMA. IJNPC [Internet]. 2019May23 [cited 2021Oct.17];1(01):07-10. Available from: