Wound Healing Herbal Formulation from Essential Oil of Lemongrass (Cymbopogon citratus)

Authors

  • Wisdawati Wisdawati Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, 90231, Indonesia
  • Rais Razak Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, 90231, Indonesia

DOI:

https://doi.org/10.32734/idjpcr.v7i1.14759

Keywords:

wound healing, ointment, essential oil, lemongrass, Cymbopogon citratus

Abstract

Untreated wound may lead to the infection. In some countries, plants are used to cure wound traditionally. Lemongrass (Cymbopogon citratus) has various bioactive compounds, including citronellol, limonene and geraniol that perform some pharmacological activities. In this study, the essential oil of lemongrass was designed into ointment formulation since lemongrass has been reported to have a wound healing effect in mice. The wound healing ointment made from different concentration of the essential oil of Cymbopogon citratus (F1: EOCC 5%, F2: EOCC 10% and F3: EOCC 15%) using a water-removable base and the characteristic as well as the stability (texture, color, smell, homogeneity, and pH) after been stored for 14 days was also evaluated. The result showed that all formulation (F1, F2, and F3) of wound healing formulation revealed good texture, consistency, odor, color, homogeneity and compatible to the skin until 14 days of storage. However, F3 (EOCC 15%) has a strong lemongrass smell compare to the other formulations.

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References

E. M. Tottoli, R. Dorati, I. Genta, E. Chiesa, S. Pisani, and B. Conti, ‘Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration’, Pharmaceutics, vol. 12, no. 8, p. 735, Aug. 2020, doi: 10.3390/pharmaceutics12080735.

A. C. de O. Gonzalez, T. F. Costa, Z. de A. Andrade, and A. R. A. P. Medrado, ‘Wound healing-A literature review’, An. Bras. Dermatol., vol. 91, pp. 614–620, 2016.

G. Han and R. Ceilley, ‘Chronic Wound Healing: A Review of Current Management and Treatments’, Adv. Ther., vol. 34, no. 3, pp. 599–610, 2017, doi: 10.1007/s12325-017-0478-y.

R. Wintoko and A. D. N. Yadika, ‘Manajemen terkini perawatan luka’, J. Kedokt. Univ. Lampung, vol. 4, no. 2, pp. 183–189, 2020.

A. Shedoeva, D. Leavesley, Z. Upton, and C. Fan, ‘Wound Healing and the Use of Medicinal Plants’, Evid. Based Complement. Alternat. Med., vol. 2019, p. 2684108, 2019, doi: 10.1155/2019/2684108.

V. E. Kaban, N. Nasri, Z. Rani, N. Suci, E. S. K. Sekali, and H. U. B. Sagala, ‘The effect of turmeric parent extract gel (Curcuma longa Linn) on incision wound healing in male white rats (Rattus norvegicus)’, J. Pharm. Sci., pp. 616–627, 2024.

O. S. Oladeji, F. E. Adelowo, D. T. Ayodele, and K. A. Odelade, ‘Phytochemistry and pharmacological activities of Cymbopogon citratus: A review’, Sci. Afr., vol. 6, p. e00137, Nov. 2019, doi: 10.1016/j.sciaf.2019.e00137.

E. Lulekal et al., ‘Phytochemical analysis and evaluation of skin irritation, acute and sub-acute toxicity of Cymbopogon citratus essential oil in mice and rabbits’, Toxicol. Rep., vol. 6, pp. 1289–1294, 2019, doi: 10.1016/j.toxrep.2019.11.002.

K. Manvitha and B. Bidya, ‘Review on pharmacological activity of Cymbopogon citratus’, Int. J. Herb. Med., vol. 1, pp. 5–7, 2014.

D. S. F. Paqita, ‘Pengaruh Ekstrak Sereh (Cymbopogon Citratus) terhadap Jumlah Fibroblas pada Penyembuhan Luka Mukosa Oral Tikus Putih’, Universitas Sumatera Utara, 2021.

P. A. Handayani and H. Nurcahyanti, ‘Ekstraksi minyak atsiri daun zodia (Evodia suaveolens) dengan metode maserasi dan distilasi air’, J. Bahan Alam Terbarukan, vol. 3, no. 1, pp. 1–7, 2014.

Kementerian Kesehatan Republik Indonesia, Farmakope Herbal Indonesia, 2nd ed. Jakarta, 2017.

S. Susanti, W. Hajrin, and N. I. Hanifa, ‘FORMULASI DAN EVALUASI SEDIAAN SALEP EKSTRAK ETANOLIK DAUN TEKELAN (Chromolaena odorata L.)’, J. Ilmu Farm. Dan Farm. Klin., vol. 19, no. 2, pp. 88–94, 2022.

D. P. Astuti, P. Husni, and K. Hartono, ‘Formulasi dan uji stabilitas fisik sediaan gel antiseptik tangan minyak atsiri bunga lavender (Lavandula angustifolia Miller)’, Farmaka, vol. 15, no. 1, pp. 176–184, 2017.

N. Lumentut, H. J. Edi, and E. M. Rumondor, ‘Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya’, J. MIPA, vol. 9, no. 2, p. 42, Mar. 2020, doi: 10.35799/jmuo.9.2.2020.28248.

D. Maliana, N. Nuryanti, and H. Harwoko, ‘Formulasi sediaan krim antioksidan ekstrak etanolik daun Alpukat (Persea americana Mill.)’, Acta Pharm. Indones., vol. 4, no. 2, pp. 7–15, 2016.

M. Mukarram et al., ‘Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities’, Antioxidants, vol. 11, no. 1, p. 20, Dec. 2021, doi: 10.3390/antiox11010020.

M. Hairi, N. Dewi, and H. Khatimah, ‘Pengaruh ekstrak sereh (Cymbopogon citratus) terhadap panjang luka mukosa labial mencit secara klinis’, Dentino J. Kedokt. Gigi, vol. 1, no. 2, pp. 90–95, 2016.

M. De Villiers, ‘Ointment Bases’, 2009, pp. 277–290.

V. E. Kaban, N. Nasri, K. Gurning, H. D. Syahputra, and Z. Rani, ‘Formulasi Sediaan Lip Cream Ekstrak Daun Miana (Coleus scuatellariodes [L] Benth.) sebagai Pewarna Alami’, INSOLOGI J. Sains Dan Teknol., vol. 1, no. 4, pp. 393–400, 2022.

T. T. K. Ngan, T. T. Hien, P. H. Danh, L. T. H. Nhan, and L. X. Tien, ‘Formulation of the Lemongrass (Cymbopogon citratus) essential oil-based eco-friendly diffuse solution’, in IOP Conference Series: Materials Science and Engineering, IOP Publishing, 2020, p. 012024.

S. I. P. Rahmani and A. K. Zulkarnain, ‘Optimization of HPMC and Na-CMC as Gelling Agents on Physical Properties and Stability in Sunflower Seed Oil Gel Formulation’, J. Food Pharm. Sci., vol. 11, no. 2, Jun. 2023, doi: 10.22146/jfps.8227.

R. Fitri, H. D. Syahputra, N. Nasri, V. E. Kaban, and Z. Rani, ‘Formulation of a biocellulose mask containing the essence of Aloe vera (L.) Burm. f combination with vitamin E as anti-aging’, Sci. Pharm. Sci., no. 6 (40), pp. 36–42, 2022.

Published

2024-11-16

How to Cite

Wisdawati, W., & Razak, R. (2024). Wound Healing Herbal Formulation from Essential Oil of Lemongrass (Cymbopogon citratus). Indonesian Journal of Pharmaceutical and Clinical Research, 7(1), 1-6. https://doi.org/10.32734/idjpcr.v7i1.14759