Formulasi dan Uji Aktivitas Anti-aging Sediaan Hand Cream yang Mengandung Ekstrak Etanol Kulit Buah Nanas (Ananas comosus (L.) Merr.)
DOI:
https://doi.org/10.32734/idjpcr.v7i1.17790Keywords:
Hand cream, Pineapple Peel (Ananas comosus L.) Merr, Anti-Aging, FormulationAbstract
Hand skin that is often exposed to the sun easily loses moisture and is more rough. Hand cream is a care product that is applied to the palms and backs of the hands that can help restore hydration and skin function due to dry and rough skin. Pineapple peel contains flavonoids, vitamin C, and bromelain enzymes that has potential to be formulated into anti-aging preparations. This research aims to formulate ethanol extract of pineapple peel (Ananas comosus (L.) Merr.) into hand cream and to test the effectiveness as anti-aging agent. This research included making extracts by percolation method using 70% ethanol solvent, testing the antioxidant activity of pineapple peel extract using DPPH method, and hand cream formulations with the addition of pineapple peel extract with respective concentration of 0% (F0), 5% (F1), 7.5% (F2), and 10% (F3). Evaluation of hand cream preparations included organoleptic test, homogeneity, emulsion type, pH, viscosity, and physical stability at room temperature storage for 12 weeks and cycling test. Anti-aging effectiveness testing was carried out during the 4 weeks treatment period, by measuring parameters such as moisture, pores, blemishes and wrinkles on the skin of the backs of volunteers' hands which were measured once a week using a skin analyzer. The results of the antioxidant activity test of the ethanol extract of pineapple peel were included in the strong category with an IC50 value of 88.21 µg/mL. The hand cream preparation produced was homogeneous, O/W emulsion type, pH value 5.09-6.56, viscosity value 4086.76-6104.96 cPs, stable during 12 weeks of storage at room temperature and stable in the cycling test for 4 weeks. Hand cream preparations with a concentration of 10% have better effectiveness than 0%, 5% and 7.5% which results in an average percent moisture recovery of 77.60%, pores 62.92%, blemishes 55.65%, and wrinkles 45.92%.
Downloads
References
Muliyawan, D., Suriana, N. 2013. A-Z tentang Kosmetik. Jakarta: Gramedia. Halaman 21-22.
Shabanikakroodi, S., Christianus, A., Tan, C.P., Ehteshami, F. 2018. Effect of Using Various Amounts of Patin (Pangasianodon hypophthalmus) Fish Oil on Physical and Chemical Properties of Moisturizing Hand Cream. Iranian Journal of Fisheries Sciences. 18(2): 216.
Paramitha, D.A.I., Sibarani, J., Suaniti, N.M. 2017. Sifat Fisikokimia Hand and Body Cream dengan Pemanfaatan Ekstrak Etanol Bunga Gemitir (Tagetes erecta L.) dan Bunga Pacar Air Merah (Impatiens balsamina L.) dari Limbah Canang. Cakra Kimia 5(1): 2.
Abbas, S., Shanbhag, T., Kothare, A. 2020. Applications of Bromelain from Pineapple Waste Towards Acne. Saudi Journal of Biological Sciences. 28(1): 1.
Ditjen POM RI. 1979. Farmakope Indonesia. Edisi Ketiga. Jakarta: Departemen Kesehatan Republik Indonesia. Halaman 33.
Molyneux, P. 2004. The Use of The Stable Free Radical Diphenylpicrylhydrazyl (DPPH) For Estimating Antioxidant Activity. Songklanakarin Journal Science Technology. 26(2): 211-219.
Tambunan, R.M., Swandiny, G.F., Zaidan, S. 2019. Uji Aktivitas Antioksidan dari Ekstrak Etanol 70% Herba Meniran (Phyllanthus niruri L.) Terstandar. Saintech Farma. 12(2): 62.
Andhasari, Y. 2013. Formulasi dan Uji Efek Anti-aging dari Sediaan Hand Cream Ekstrak Daun Teh Hijau (Camelia sinensis L.). Skripsi. Fakultas Farmasi. Universitas Sumatera Utara. [10] Tambunan, R.M., Swandiny, G.F., Zaidan, S. 2019. Uji Aktivitas Antioksidan dari Ekstrak Etanol 70% Herba Meniran (Phyllanthus niruri L.) Terstandar. Saintech Farma. 12(2): 62.
Diana, V. E., Ginting, M., Iskandar, B., Fadhila, C., dan Leny. 2022. The Effectiveness of Pandan Wangi Leaves (Pandanus amaryllifolius Roxb.) Body scrub Formulation in Smoothing the Skin. Asian Journal of Pharmaceutical Research and Development. 10(1): 2.
Tanjung, Y.P., Akmal, P., Virginia, H. 2022. Formulation of Hand Cream Essential Oil of Basil (Ocimum basilicum) Leave. Indonesian Journal of Pharmaceutical Science and Technology. 1(1): 38..
Rawlins, E.A. 2003. Bentley’s Textbook of Pharmaceutics. London: Bailierre Tindall. Halaman 355.
Nurfita, E., Mayefis, D., Umar, S. 2021. Uji Stabilitas Formulasi Hand and Body Cream Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus lemairei). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia. 8(2): 127.
Apriani, E.F., Nurleni, N., Nugrahani, H.N., Iskandarsyah. 2018. Stability Testing of Azelaic Acid Cream Based Ethosome. Asian Journal of Pharmaceutical and Clinical Research. 11(5): 271.
National Health Surveillance Agency. 2005. Cosmetic Products Stability Guide. First Edition. Brazil: ANVISA. Halaman 18-21.
Wasitaatmadja, S.M. 1997. Penuntun Ilmu Kosmetik Medik. Jakarta: Penerbit UI Press. Halaman 111.
Gandjar, I.G., dan Rohman, A. 2018. Spektroskopi Molekuler untuk Analisis Farmasi. Yogyakarta: Gadjah Mada University Press. Halaman 11.
Marxen, K., Vanselow, H., Lippemeier, S., Hintze, R., Ruser, A., Hansen, U. 2007. Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements. Sensors. 7: 2081.
Lorenzo, C., Badea, M., Colombo, F., Orgiu, F., Frigerio, G., Pastor, R., dkk. 2017. Antioxidant Activity of Wine Assessed by Different In Vitro Methods. BIO Web of Conferences. Halaman: 2, 3, 5.
Samarakoon, S.M.G.K., Rajapakse, C.S.K. 2020. Exploration of Antioxidant Activity and Photoprotective Potential of Methanolic Extract of Ananas comosus (Pineapple) Peel. In: International Conference on Applied and Pure Sciences, 2020. Faculty of Science. University of Kelaniya.
La, J.W., Kim, M.J., Lee, J.H. 2021. Evaluation of Solvent Effects on the DPPH Reactivity for Determining the Antioxidant Activity in Oil matrix. Food Science and Biotechnology. 30(3): 367.
Ulandari, A.S., Sugihartini, N. 2020. Evaluasi Sifat Fisik Sediaan Lotion Dengan Variaso Konsentrasi Ekstrak Daun Kelor (Moringa oleifera L.) Sebagai Tabir Surya. Jurnal Farmasi Udayana. 9(1): 45.
Tranggono, R. I. S., dan Latifah, F. 2014. Buku Pegangan Dasar Kosmetologi. Jakarta: Sagung Seto. Halaman 6-7, 9-12, 63.
Noer, B. M., dan Sundari. 2016. Formulasi Hand Body Lotion Ekstrak Kulit Buah Naga Putih (Hylocereus undatus) dan Uji Kestabilan Fisiknya. Jurnal Kesehatan. 11(1): 110.
Aramo. (2012). Skin and Hair Diagnostic System. Sugnam: Aram Huvis Korea Ltd. Halaman 1-10.
Tricaesario, C. 2016. Efektivitas Krim Almond Oil 4% terhadap Tingkat Kelembapan Kulit. Jurnal Kedokteran Diponegoro. 5(4): 599.
Gabrielle, Arijana, K., Sugiritama, I., Ratnayanti, A. 2023. Pengaruh Krim Topikal Daun Kelor Terhadap Kelembapan Kulit yang Terpapar Sinar Ultraviolet B. Jurnal Medika Udayana. 12(11): 106.
Kyuho, Y., Hyungku, B., Sungyeon, K., Hyunjun, P., Jeunghyun, Y., Hyunjin C. 2023. A Novel Microcoring Technology: A Completely New Concept of Enlarged Pore Treatment. Journal of Cosmetic Dermatology. 22(7): 2004.
Febriani, Y., Sembiring, S.R. 2021. Formulasi dan Uji Aktivitas Antioksidan Sediaan Masker Clay Ekstrak Etanol terong Belanda (Solanum betaceum Cav.). Indonesian Journal of Pharmaceutical Science and Technology. 1(1): 28.
Sitanggang, T. C. 2019. Krim Astaxanthin Mencegah Peningkatan Melanin Kulit Marmut (Cavia porcellus) yang Dipapar Sinar Ultraviolet B. Jurnal Media Sains. 3(2): 72.
Prianto, J. 2014. Cantik Panduan Lengkap Merawat Kulit Wajah. Jakarta: Gramedia. Halaman 129.
Nashar, H.A., Gamal, M., Hritcu, L., Eldahshan, O. 2021. Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity. Molecules. 26(24): 7546.
Sanadi, R.M., Deshmukh, R.S. 2020. The effect of Vitamin C on melanin pigmentation: A systematic review. Journal of Oral and Maxillofacial Pathology. 24(2): 374
Liliana, N., Wiraguna, A., Pangkahila, W. 2017. Krim Ekstrak Panax Ginseng Menghambat Peningkatan Ekspresi MMP-1 dan Penurunan Jumlah Kolagen pada Tikus Wistar Jantan (Rattus norvegicus) yang Dipajan Sinar UV-B. Jurnal e-Biomedik. 5(1): 5.
Noormindhawati, L. 2013. Jurus Ampuh Melawan Penuaan Dini. Jakarta: PT Elex Media Komputindo. Halaman 15-16.
Fitri, R. ., Reveny, J., Harahap, U., Dharmawan, H., & Nasri. (2021). Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E. Indonesian Journal of Pharmaceutical and Clinical Research, 4(1), 1-7.
Kaban, V., N, N., Dharmawan, H., & Satria, D. (2022). Formulasi dan Uji Efektivitas Sabun Pencuci Tangan dari Ekstrak Daun Pandan (Pandanus amaryllifolius Roxb.) Terhadap Bakteri Salmonella sp. Herbal Medicine Journal, 5(1), 8-12.
Published
How to Cite
Issue
Section
Copyright (c) 2024 Indonesian Journal of Pharmaceutical and Clinical Research
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) and Faculty of Pharmacy as well as TALENTA Publisher Universitas Sumatera Utara as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR).
The Copyright Transfer Form can be downloaded here.
The copyright form should be signed originally and sent to the Editorial Office in the form of original mail or scanned document.
