Identifikasi Drug Related Problems Pada Pasien Penyakit Ginjal Kronis Di Rumah Sakit Prof. dr. Chairuddin Panusunan Lubis Tahun 2023

Singgar Ni Rudang; Rima Elfitra Rambe; Sheyla Annisa

doi:10.32734/idjpcr.v7i1.18031

Authors

Singgar Ni Rudang Departemen Farmakologi dan Farmasi Klinis/Komunitas, Fakultas Farmasi, Universitas Sumatera Utara, Medan, 20155, Indonesia
Rima Elfitra Rambe Departemen Farmakologi dan Farmasi Klinis/Komunitas, Fakultas Farmasi, Universitas Sumatera Utara, Medan, 20155, Indonesia
Sheyla Annisa Program Sarjana, Fakultas Farmasi, Universitas Sumatera Utara, Medan, 20155, Indonesia

DOI:

https://doi.org/10.32734/idjpcr.v7i1.18031

Keywords:

Drug-Related Problems, Chronic Kidney Disease, PCNA V9.1

Abstract

Chronic kidney disease (CKD) is an abnormality of kidney structure or function, present for ≥ 3 months, with implications for health. The high number of medications used by CKD patients can increase the potential for Drug-Related Problems (DRPs) which can interfere with desired health outcomes. This study aimed to determine the occurrence of DRPs in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023. This study was a descriptive retrospective cross-sectional study conducted. Data were obtained from the medical records of CKD inpatients in 2023 (n=51). The sampling technique used was total sampling. The occurrence of DRPs was identified based on the Pharmaceutical Care Network Europe (PCNE) V9.1 classification, which includes problems categories (P1-P3) and causes (C1-C6). There were 28 females (54.90%) and 23 males (45.10%), with an average age of 46.8±11.5 years. The highest stage of CKD was stage 5 (78.43%). The most common comorbid condition was anemia (84.31%), with the most frequently used medication being antihypertensives in the Calcium Channel Blocker class (88.24%). Among the 51 medical records, 21 (41,17%) showed the occurrence of DRPs, consisting of 26 Problems (P) categorized under P1. Treatment effectiveness (46,15%) and P2. Treatment safety (53,85%), and 26 Causes (C) categorized under C1. Drug selection (57,69%) and C3. Dose selection (42,31%). Drug-Related Problems (DRPs) occurred in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023.

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References

Susianti, H. Memahami Interpretasi Pemeriksaan Laboratorium Penyakit Ginjal Kronis. Malang: UB Press. 2019. Halaman 11 dan 13.

RISKESDAS. Laporan Nasional Riskesdas 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Republik Indonesia. 2018. Halaman 174.

Tandah, M.R., Ihwan, Diana, K., dkk. Analisis Biaya Pengobatan Penyakit Ginjal Kronik Rawat Inap Dengan Hemodialisis di Rumah Sakit Umum Daerah Undata Palu. Jurnal LINK. 2019;15(2):2.

Nurtandhee, M. Estimasi Biaya Pelayanan Kesehatan sebagai Upaya Pencegahan Defisit Dana Jaminan Sosial untuk Penyakit Gagal Ginjal. Jurnal Jaminan Kesehatan Nasional. 2023;3(2):84.

Papotti, B., Marchi, C., Adorni, M.P., dkk. Drug-drug interactions in polypharmacy patients: The impact of renal impairment. ELSEVIER. 2021;2:3.

Subeesh, V.K., Abraham, R., Sai, M.V.S., dkk. Evaluation of prescribing practices and drug‑related problems in chronic kidney disease patients: A cross‑sectional study. Perspectives in Clinical Research. 2020;11(2):72.

Suryaningsih, N.P.A., Arimbawa, P.E., Wintariani, N.P., dkk. Analisis Drug Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronis (PGK) Rawat Inap Di Sebuah Rumah Sakit Di Bali. Jurnal Ilmiah Medicamento. 2019;5(2):77.

van Mil, J.W.F., Horvat, N., Westerlund, T., dkk. Classification for Drug related problems. Zuidlaren: Pharmaceutical Care Network Europe Association. 2020. Halaman 1-9.

Jayaningsih, V., dan Palupi, P.D. Analisa Drug Related Problems (DRPs) Pada Pasien Chronic Kidney Disease (CKD) di Instalasi Rawat Inap Klinik Sari Medika Kabupaten Semarang. Jurnal Farmasi dan Sains Indonesia. 2021;4(1):3.

Zhang, S., Huang, P., Ren, Y., dkk. 2022. Drug Related Problems in Hospitalized Patients with Kidney Diseases and Clinical Pharmacists' Services a Prospective Study in China. Research Square.

IRR. 11th Report of Indonesian Renal Registry. Jakarta: PERNEFRI. 2018. Halaman 11 dan 18.

Diputra, A.A., Sari, I.P., Nurulita, N.A. Analisa Drug Related Problem (DRPs) Pada Pasien Gagal Ginjal Kronis Stadium Akhir Yang Menjalani Hemodialisa di RSUD 45 Kuningan. Journal of Pharmacopolium. 2020;3(3):110.

Po-Ya, C., Li-Nien, C., Yuh-Feng, L., dkk. Risk factors of gender for renal progression in patients with early chronic kidney disease. Medicine. 2016;95(30):2.

Devi, S., dan Rahman, S. Hubungan Lama Menjalani Terapi Hemodialisis Dengan Kualitas Hidup Pasien Penyakit Ginjal Kronis di Rumah Sakit Khusus Ginjal Rasyida. Jurnal Ilmiah Kohesi. 2022;6(1): 64.

Artiany, S., Aji, Y.G.T., dan Yenny. Gambaran Komorbid pada Pasien Hemodialisis di Rumah Sakit Angkatan Udara (RSAU) dr Esnawan Antariksa. Jurnal Keperawatan Cikini. 2021;2(2):1.

Sinaga, C.R. EQ-5D-5L untuk Pengukuran Biaya dan Indeks Utilitas pada Pasien Gagal Ginjal Kronis dengan Hemodialisis. Jurnal Penelitian Kesehatan Suara Forikes. 2023;14(2):288.

Maharianingsih, N.M., Dewi, N.K.S. Evaluasi Penggunaan Obat Anemia Pada Pasien Penyakit Ginjal Kronis Dengan Hemodialisa di RSU Ari Canti Pada Tahun 2020. Jurnal Farmasi dan Kesehatan. 2021;10(2):3.

JNC VIII. Joint National Committee VII Hypertension Guideline Algorithm. 2014;311(5).

McCauley, J., Hamrahian, S.M., dan Maarouf, O.H. Approaches to Chronic Kidney Disease. Springer: Switzerland. 2022. Halaman 104-105.

Kadir, A. Hubungan Patofisiologi Hipertensi Dan Hipertensi Renal. Jurnal Ilmiah Kedokteran. 2016;5(1):16-20.

Saputra, S.I., Berawi, K.N., Susianti, dkk. Hubungan Diabetes Melitus dengan Kejadian Gagal Ginjal Kronis. Medical Profession Journal of Lampung. 2023;13(5):789.

Kumar, M., Dev, S., Khalid, M.U., dkk. 2023. The Bidirectional Link Between Diabetes and Kidney Disease: Mechanisms and Management. Cureus. 2023;15(9):1,3.

Ohno, S., Ishii, A., Yanagita, M., dkk. Calcium channel blocker in patients with chronic kidney disease. Springer. 2022;26(3):207.

Sari, I.P., dan Febrina, E. Review: Penggunaan Off-Label Obat Golongan Antagonis Reseptor Histamin 2. Journal Of Pharmaceutical and Sciences. 2023;6(1):267,270.

Khalid, M.A., Iqbal, J., Memon, H.L., dkk. Dyspepsia Amongst End Stage Renal Disease Undergoing Hemodialysis: Views from a Large Tertiary Care Center. Journal of Translational Internal Medicine. 2018;6(2):81.

Syed-Ahmed, M., dan Narayanan, M. Immune Dysfunction and Risk of Infection in Chronic Kidney Disease. National Kidney Foundation. 2019;26(1):8,10.

Wicaksono, A.A., dan Baroroh, F. The Effectiveness of Amlodipine and Nifedipin on Hypertension Outpatients at Public Health Centre. Prosiding Seminar Nasional Farmasi Universitas Ahmad Dahlan. 2023;2:13.

KDIGO. Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Official Journal of the International Society of Nephrology. 2012;2(5): 341.

Jamaluddin, G., Zulmansyah, dan Nalapraya, W.Y. Perbandingan Efektivitas Insulin, Obat Antidiabetik Oral dan Kombinasi terhadap Kadar Gula Darah pada Pasien Rawat Jalan dengan DM Tipe 2 RSUD Al-Ihsan. Bandung conference series: Medical science. 2022;2(1):511.

Dewi, R., Andriani, M., dan Oktaviazmi, S.P. Analisis Efektivitas Biaya Penggunaan Antibiotik Ceftriaxone Dan Gentamisin Pada Pasien Pneumonia Anak Rawat Inap Rumah Sakit X di Jambi Tahun 2018. Pharma Xplore. 2021;6(1):44.

Arya, N.P., dan Pratama, Y.A.A.G.W. Anemia Defisiensi Besi: Diagnosis dan Tatalaksana. Ganesha Medicina Journal. 2022;2(1):50.

Adiwardhana, J., dan Wreksoatmodjo, B.R. Efek Neurologis Hipokalemia dan Hiperkalemia. Cermin Dunia Kedokteran. 2023;50(10):556,558.

Rosyada, N.A., Purwantiningsih, dan Andayani, T.M. Penyesuaian Dosis Obat Pasien Penyakit Ginjal Kronik di RSUD Kardinah Tegal. Majalah Farmaseutik. 2023;19(2):238.

Rengga, M.P.E., Kono, R.B., dan Beama, C.A. Analisis Interaksi Obat Penyakit Ginjal Kronik di RSUD Prof. Dr. W. Z. Johannes Kupang. Media Pharmaceutica Indonesiana. 2021;3(3):180.

Hahr, A.J., dan Molitch, M.E. Management of Diabetes Mellitus in Patients With CKD: Core Curriculum 2022. American Journal of Kidney Diseases. 2022;79(5):734.

Baker, M., dan Perazella, M.A. NSAIDs in CKD: Are They Safe? American Journal of Kidney Diseases. 2022;76(4):547.

Golightly, L.K., Teitelbaum, I., dan Simendinger, B.A., dkk. Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidney. New York: Springer. 2022. Halaman 421 dan 473.

Kemenkes RI. Pedoman penggunaan Antibiotik. Jakarta: Menteri Kesehatan Republik Indonesia. 2021.

Danial, N.F., Hidayati, P.H., Mulyadi, F.E., dkk. Gambaran Kultur Bakteri dan Sensitivitas Antibiotik pada Pasien Sepsis di Rumah Sakit Ibnu Sina Periode 2019-2022. Alami Journal: Alauddin Islamic Medical Journal. 2024;8(1):41.

Setiadi, A., Prasanti, R.W., Wikaningtyas, P. Analisis Drug’s Related Problems (DRPS’s) Pada Pasien Dengan Kasus Chronic Kidney Disease (CKD) di Ruang Rawat Inap Rumah Sakit Bhayangkara TK Ii Sartika Asih Kota Bandung. Pharmacoscript. 2023; 6(2):128,132.

Reyaan, I.B.M., Kuning, C., Adnyana, I.K. Studi Potensi Interaksi Obat Pada Resep Polifarmasi di Dua Apotek Kota Bandung. Jurnal Manajemen dan Pelayanan Farmasi. 2021;11(3):146.

Medscape. 2024. Drug interaction checker. [online]. https://reference.medscape. com/drug- interactionchecker.

Denny, D.C., Balamanikandan, G., Radhakrishnan, M., dkk. Role of Pharmacist Interventions in Drug Related Problem among Chronic Kidney Disease Patients. Indian Journal of Pharmacy Practice. 2022;15(3):214.

Shiferaw, W.S., Akalu, T.Y., dan Aynalem, Y.A. Risk Factors for Anemia in Patients with Chronic Renal Failure: A Systematic Review and Meta-Analysis. Ethiopian Journal of Health Science. 2020;30(5):830.

Yuniarti, W. Anemia Pada Pasien Gagal Ginjal Kronik. Journal Health And Science. 2021;5(2): 345.

Mahindisyah, M.G., Humairah, I., Tjempakasari, A., dkk. The Relationship between Hyperuricemia and Hypertension in Internal Medicine Policlinic Patients in RSUD Dr. Soetomo 2019- 2021. Formosa Journal of Science and Technology. 2024;3(1):8-9.