OPTIMASI DAN FORMULASI GRANUL DAUN SINGKONG (Manihot esculenta Crantz) DENGAN KOMBINASI MANITOL, SUKROSA DAN MADU
DOI:
https://doi.org/10.32734/idjpcr.v7i2.18035Keywords:
Daun singkong, Streptococcus mutans, granulAbstract
Tanaman daun singkong (Manihot esculenta Crantz) merupakan salah satu tumbuhan obat yang digunakan secara turun temurun. Secara farmakologi daun singkong mempunyai aktivitas sebagai antiinflamasi, antibakteri, antioksidan. Pada penelitian ini metode yang digunakan adalah eksperimental. Formula granul diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi di formulasi secara konvensional dan diuji karakteristik fisiknya. Hasil penelitian ini menunjukkan bahwa formula optimum granul yang diperoleh yaitu dengan konsentrasi manitol 14%, sukrosa 5,4% dan madu 2,6%. Hasil uji evaluasi yang diperoleh indeks tap 10%, waktu alir 3.58 detik dan sudut diam 24.42o. Hasil pengujian menggunakan Uji-t one sample pada software SPSS Statistic® didapati bahwa nilai p>0,05 sehingga data dinyatakan tidak berbeda signifikan .Hasil pengujian antibakteri menunjukkan bahwa formula optimum memiliki daya hambat yang kuat.
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