Evaluation of Antiinflammatory Activity of Marine Omega-3 in Rats
Keywords:Antiinflammatory, Fish Oil, Marine Omega-3, Sodium Diclofenac
Marine omega-3 from fish contains high EPA dan DHA which may have an analgesic and anti-inflammatory effects. The objective of study is to analyze the anti-inflammatory effect of marine omega-3 in rats. The method of this study is pre-post control experimental. The acute anti-inflammatory effect of marine omega-3 were investigated through carrageenan induced paw edema in rats. Thirty minutes before the procedure, the experimental groups were treated with fish oil 40 and 60 mg/kg; sodium diclofenac (5 mg/kg) as positive control groups and span 80-tween 80 as negative control groups. The degree of paw edema was measured by caliper. The marine omega-3 showed anti-inflammatory effect in a dose-dependent manner. The results of 60 mg/kg of marine omega-3 was significantly different compared with the negative. Overall,
the marine omega-3 has acute anti-inflammatory activity in rats.
 K. Yamagata, K. Ishida, H. Takashi, S. Ohba, T. Shiigai, M. Narita, A. Koyama, Risk factor for chronic kidney disease in a community-based population : a 10 year follow-up study, Kidney Int. Vol 71 No. 2. Pp 159-166. 2007.
 S. Hamid, J. Yakoob, W. Jafri, S. Abid, M. Islam, Frequency of NSAID induced peptic ulcer disease. J Pak Med Assoc. Vol. 56 No. 5. Pp. 218-222. 2006.
 KKP, 2016. Laporan Kinerja Kementrian Kelautan dan Perikanan, Kementrian Kelautan dan Perikanan Republik Indonesia, Jakarta. pp. 132-136. 2015.
 WS. Haris, “Review: Fish Oil Supplementation: Evidence For Health Benefits” Cleveland Clinic J. of Medicine, vol. 71, No. 3, pp 208-219. 2004.
 J. Necas, L. Bartosikova, “Carragenan: a review” Veterinarni Medicina, vol. 58, pp. 187-205. 2013.
 JA. Aberg, CF Lacy, LL. Amstrong, MP. Goldman, and LL. Lance, Drug Information Handbook, 17th edition, Lexi-Comp for the American Pharmacists Association. 2009.
 MM. Azuma, G. JE, E. Ervolino, CBM. Cardoso, CB. Pipa, T. Kawai, LC. Conti, LTA. Cintra, Omega-3 fatty acids reduce inflammation in rat apical periodontitis, J Endod. Vol. 44 No. 4. Pp 604-608. 2017.
 L. Arruda, FQ Ames, DR. Morais, R. Grespan, AP. Gil, MA. Silva, JV. Visentainer, RK. Cumn, CA. Bersani-Amado, “ A single adminidtration of fish oil inhibits the acute inflammatory response in rats”, Asian Pacific Journal of Tropical Medicie, vol. 10 No. 8 pp 765-772. 2017.
 P.C. Calder, “Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance” Biochim Biophys Acta. Vol. 4. pp. 469-484. 2015.
 M. Massaro, E. Scoditti, M.A. Carluccio, R. De Caterina. “Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease” Prostagl Leukot Essent Fat Acids, vol. 79 No. 3–5.pp. 109-115. 2008.
How to Cite
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) and Faculty of Pharmacy as well as TALENTA Publisher Universitas Sumatera Utara as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR).