Anti Acne Vulgaris Topical Cream From Combination Extract of Gymnanthemum Amygdalinum Del. and Elaeis Guineensis Jacq. Leaves

Wahyudi; Ayu Syahfitri; Syukur  Berkat Waruwu; Dian Ika Perbina

doi:10.32734/idjpcr.v3i1.4048

Authors

Wahyudi Department of Pharmaceutical, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Indonesia
Ayu Syahfitri Department of Pharmaceutical, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Indonesia
Syukur Berkat Waruwu Department of Pharmaceutical, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Indonesia
Dian Ika Perbina

DOI:

https://doi.org/10.32734/idjpcr.v3i1.4048

Keywords:

Gymnanthemum Amygdalinum Del., Elaeis Guineensis Jacq., Topical Cream, Acne Vulgaris.

Abstract

Acne is one problem in adolescents and adults who can reduce self-confidence. This study aimed to formulate the combination cream of African leaf extract and palm oil leaves to determine the antibacterial activity of African leaf extract against several acne-causing bacteria (Propionibacterium acne and Staphylococcus epidermidis). Test antibacterial activity of extracts and cream with disc diffusion method. The cream is made with concentration of 5, 10 and 20% w/w. The evaluation results of cream with concentration of 5, 10 and 20% were physically stable for 4 weeks of storage at temperature room, homogeneous, pH and it did not cause irritation. Based on the test results, a combination of African leaf extract with concentration of 5% effectively inhibited bacterial growth with an average inhibition zone diameter of 12.06 mm for Propionibacterium acne bacteria and 13.63 mm for Staphylococcus epidermidis bacteria. The result of this study suggest that combination of African leaf extract and palm leaves posses potent anti-bacterial activity against Propionibacterium acne and Staphylococcus epidermidis.

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References

. S. M. Gallitano and D. S. Berson, “How Acne Bumps Cause the Blues: The Influence of Acne Vulgaris on Self-Esteem,” International Journal of Women’s Dermatology, vol. 4, no. 1, pp. 12–17, 2018.

. E. Tasoula, S. Gregoriou, J. Chalikias, D. Lazarou, I. Danopoulou, A. Katsambas, and D. Rigopoulos, “The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece: results of a population survey,” Anais Brasileiros de Dermatologia, vol. 87, no. 6, pp. 862–869, 2012.

. M. Webster, “Self-esteem”, 2017. [Online].Available: https://www.merriam-webster.com/dictionary/ self-esteem;

. P. Praptiwi, A. Fathoni, and M. Ilyas, “Diversity of endophytic fungi from Vernonia amygdalina, their phenolic and flavonoid contents and bioactivities,” Biodiversitas Journal of Biological Diversity, vol. 21, no. 2, Jan. 2020.

. N. Swelankomo, J. C. Manning, and A. R. Magee, “The genus Gymnanthemum Cass. (Asteraceae: Vernonieae) in Southern Africa,” South African Journal of Botany, vol. 102, pp. 81–101, Jan. 2016.

. T. Ahmad, M. Irfan, and S. Bhattacharjee, “Parametric Study on Gold Nanoparticle Synthesis Using Aqueous Elaise Guineensis (Oil palm) Leaf Extract: Effect of Precursor Concentration,” Procedia Engineering, vol. 148, pp. 1396–1401, 2016.

. C. Feuillolay, S. Pecastaings, C. L. Gac, C. Fiorini-Puybaret, J. Luc, P. Joulia, and C. Roques, “A Myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of Propionibacterium acnes biofilms to antibiotics used in acne vulgaris,” Phytomedicine, vol. 23, no. 3, pp. 307–315, Mar. 2016.

. S. Priyam., S.Shruti., M. Nidhi., and P.Y. Narayan, “New Perspectives on Anti acne Plant Drugs: Contribution to Modern Therapeutics”, BioMed Research International.2014

. World Health Organization, “Antibiotic resistance” 2016 [Online]. Available: http://www.who.int/mediacentre/factsheets/antibiotic-resistance/en/

. M. G. Eladli, N. S. Alharbi, J. M. Khaled, S. Kadaikunnan, A. S. Alobaidi, and S. A. Alyahya, “Antibiotic-resistant Staphylococcus epidermidis isolated from patients and healthy students comparing with antibiotic-resistant bacteria isolated from pasteurized milk,” Saudi Journal of Biological Sciences, vol. 26, no. 6, pp. 1285–1290, Sep. 2019.

. A. Young., Practical Cosmetic Science, Mills and Boon Limited, London. 1972

. 12.R.I.Tranggono,dan L. Fatma, Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: Gramedia Pustaka Utama: Halaman 11, 20-21, 26-27, 131. 2007

. A.O. Barel, P. Marc, and I,M, Howard. Handbook of Cosmetics Science and Technology. New York: Informa Health Care, p 471-473. 2001

. H. Nasri, M. Bahmani, N. Shahinfard, A. Moradi Nafchi, S. Saberianpour, and M. Rafieian Kopaei, “Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences,” Jundishapur Journal of Microbiology, vol. 8, no. 11, Nov. 2015.

. M. Bek-Thomsen, H. B. Lomholt, and M. Kilian, “Acne is Not Associated with Yet-Uncultured Bacteria,” Journal of Clinical Microbiology, vol. 46, no. 10, pp. 3355–3360, Aug. 2008.