The Relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy
DOI:
https://doi.org/10.32734/jetromi.v7i1.18520Keywords:
SLC22A16, Polymorhism, Breast Cancer, Doxorubicine,Hematology ToxicityAbstract
ABSTRACT
Background Drug transporter polymorphisms are widely associated with the risk of toxicity in many chemotherapy drugs in cancer. This paper aims to assess the relationship of polymorphisms of this transporter, namely SLC22A16, which are associated with side effects of Doxorubicin-based chemotherapy drugs, namely hematological toxicity (anemia, neutropenia, leukopenia and thrombocytopenia) in breast cancer patients.
Method This cross-sectional study will be conducted by testing polymorphism using the ARMS PCR method, which will assess the distribution of AA, AG, and GG genotypes.
ResultĀ Most patient ages are under 50 years (55%), with overweight BMI (41,7%) and Batak ethnicity (43,3%). There is no relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI).
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI).