RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND IL-6 LEVELS AND EJECTION FRACTION IN HEART FAILURE PATIENTS AT ADAM MALIK HOSPITAL

Abstract

Background: Heart failure (HF) is a progressive condition marked
by anatomical and functional cardiac defects. Inflammation is a
major factor in HF development. While some research implies a link
between elevated CRP and IL-6 levels and lower ejection fraction
(EF), the results are inconsistent. This study aims to evaluate the
relationship between C-reactive protein, IL-6 levels, and EF in heart
failure patients.
Method: This cross-sectional analytic observational study was
conducted at Adam Malik Hospital to assess the relationship
between CRP and IL-6 levels and left ventricular EF (LVEF) in HF
patients.
Result: The findings showed no significant connection between
CRP and LVEF (p=0.391), implying that CRP does not directly
reflect systolic dysfunction. Conversely, IL-6 levels have a
substantial inverse connection with LVEF (p=0.001), indicating a
greater link between systemic inflammation and cardiac
performance.
Conclusion: These findings underline the importance of a
multimodal approach to HF care, including the use of inflammatory
markers for risk classification in this population. While CRP may
not be as accurate a predictor of systolic dysfunction, IL-6 appears
to be more closely related to heart failure severity.

Keywords: CRP, Ejection fraction, Heart failure, IL-6.