Association between VEGF–2578 C>A Gene Polymorphism and Lifestyle in H. Pylori Positive Gastritis Patients

Abstract

Abstract

Background: The polymorphisms make the differences in virulence and pathogenicity of H. pylori, which lead to different clinical manifestations after H. pylori infection. The aim research to assess correlation between between VEGF–2578 C>A Gene Polymorphism and life style in H. Pylori (+) Gastritis Patients.

Method: The design of this study is a cross sectional study of H. Pylori (+) Gastritis patients, independent variables is gene polymorphism VEGF-2578C>A and dependent variables are life style (age, gender, BMI and alcohol). Infection of  H. Pylori detected 14C-UBT or rapid urease test. Examination  of gene polymorphism VEGF-2578C>A by  performing DNA extraction  (Spin Column Method)  with  reagent: High Pure PCR Template through PCR  procedure.

Results: From 59 pasien  Gastritis H. Pylori (+), there is no correlation between VEGF-2578 C>A  gene  polymorphism  (consisting of CC, CA and AA) with  lifestyle  (gender, age consists of < 45 years and > 45 years,  BMI  consists of < 25 kg/m²  and  > 25 kg/m²,  alcoholic drinkers )

Conclusion: There is no correlation between VEGF–2578 C>A Gene Polymorphism and life style (age, sex, BMI and alcohol drinking) in H. Pylori (+) Gastritis Patients.