Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://talenta.usu.ac.id/jetromi <p align="justify">The Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an internationally targeted official publication with indexed by Scopus. It publishes peer reviewed articles online in an open access format. The journal will encourage both empirical and theoretical of Endocrinology, Tropical Medicine and Infectious Diseases in clinic and research. It is a peer-reviewed journal has online and ISSNs. It represents the initiative and effort of the members of the Faculty of Medicine, Universitas Sumatera Utara. The purpose of this Journal is to bring together researcher, lecturer, practitioners, health policy maker, and students interested in Endocrinology, Tropical Medicine and Infectious Diseases. The publication is particularly committed to the development of interpretative approaches to the above to mentioned issues. It does not restrict its remit to any particular methodological or theoretical orientation, but publishes both scholarly papers and more speculative pieces designed to further understanding and debate.</p> <p align="justify">The Articles in Journal of Endocrinology, Tropical Medicine and Infectious Diseases will be reviewed by experts. This journal publishes original research, review articles and case reports. We accept submissions from all over the world. All submitted articles are not in the condition of being submitted to other journals and have never been published elsewhere.</p> TALENTA Publisher, Universitas Sumatera Utara en-US Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) 2686-0872 <div id="coptf"> <p align="justify">The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to <span id="result_box" lang="en">Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI).</span></p> <p align="justify">Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI).</p> </div> Periodontal Status in Periodontitis Patients with Type 2 Diabetes Mellitus at Tiga Dolok Health Center https://talenta.usu.ac.id/jetromi/article/view/18393 <p><strong>Background:</strong> Periodontitis is an inflammation of the periodontal tissue characterized by loss of attachment and the formation of periodontal pockets. Periodontitis impairs the metabolic control of patients with diabetes mellitus by increasing inflammation and insulin resistance, according to researchers. This study aims to determine the periodontal status and level of gingival inflammation in patients with periodontitis and type 2 diabetes mellitus at the Tiga Dolok Health Center.</p> <p><strong>Method:</strong> This research is a descriptive study with a cross-sectional research design. The study's population and sample are patients with type 2 diabetes mellitus accompanied by periodontitis who visit the Tiga Dolok Health Center and meet the established inclusion and exclusion criteria, with a total sample size of 42 samples taken.</p> <p><strong>Results:</strong> The research findings indicate that the average pocket depth is 4.052 mm, the average clinical attachment loss is 5.200 mm, and the level of gingival inflammation based on the gingival index shows that 18 individuals (42.9%) fall into the mild category and 24 individuals (57.1%) fall into the moderate category. Additionally, the papillary bleeding index shows that 31 individuals (73.8%) are in the &gt;1 category, and 11 individuals (26.2%) are in the ≤1 category.</p> <p><strong>Conclusion:</strong> As you can see, the periodontal health is moderate. The pocket depth is 4.052 ± 0.402 mm, the clinical attachment loss is 5.200 ± 0.822 mm, and the gingival index shows moderate gingival inflammation. In contrast, the papillary bleeding index falls into the category of &gt;1.</p> Martina Amalia Jesika Gihon Aprelia Siagian Okie Anggie Jelita Aritonang Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-03 2025-08-03 7 3 97 105 10.32734/jetromi.v7i3.18393 The Impact of Local Wisdom Education 'Poda Na Lima' on Community Knowledge in Dengue Infection Prevention https://talenta.usu.ac.id/jetromi/article/view/20308 <p><strong>Background</strong>. Dengue remains an endemic disease in almost all countries worldwide, including Indonesia. One approach to its prevention and control is community empowerment through education. Education is most impactful when aligned with the culture and local wisdom of the target community. <em>Poda na lima</em> is a form of local wisdom practiced by the Batak Angkola-Mandailing tribe in North Sumatra Province, Indonesia. This study aims to analyze the effect of <em>poda na lima</em>-based education on community knowledge regarding dengue prevention.</p> <p><strong>Methods</strong>. Quasi-experiment with one group pretest-posttest. This study involved 68 respondents from the community in the working area of Puskesmas Sihepeng, Mandailing Natal Regency, through cluster random sampling with inclusion criteria in October – November 2024. Data were collected using questionnaires before and after the dengue education intervention with <em>poda na lima</em> and analyzed using the Wilcoxon signed rank test with the SPSS software.</p> <p><strong>Result</strong>. Most of the respondents were in the age range of 19 – 45 years (80.9%), with a female gender (100%) and an education level of high school graduate (39.7%). There was an increase in the average knowledge before and after dengue education with the <em>poda na lima</em>, with statistically significant results (p&lt;0.05) and an effect size &gt; 0.5, meaning that the dengue education with the <em>poda na lima</em> has a large effect on the improve in knowledge.</p> <p><strong>Conclusion</strong>. Dengue education with local wisdom <em>poda na lima</em> has a significant and large effect on improving community knowledge.</p> Majidah Andilaila Daulay Rina Amalia Caromina Saragih Rina Amelia Ayodhia Pitaloka Pasaribu Fithri Hervianti Veralia Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-01 2025-08-01 7 3 106 114 10.32734/jetromi.v7i3.20308 RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND IL-6 LEVELS AND EJECTION FRACTION IN HEART FAILURE PATIENTS AT ADAM MALIK HOSPITAL https://talenta.usu.ac.id/jetromi/article/view/20467 <p><strong>Background</strong>: Heart failure (HF) is a progressive condition marked<br />by anatomical and functional cardiac defects. Inflammation is a<br />major factor in HF development. While some research implies a link<br />between elevated CRP and IL-6 levels and lower ejection fraction<br />(EF), the results are inconsistent. This study aims to evaluate the<br />relationship between C-reactive protein, IL-6 levels, and EF in heart<br />failure patients.<br /><strong>Method</strong>: This cross-sectional analytic observational study was<br />conducted at Adam Malik Hospital to assess the relationship<br />between CRP and IL-6 levels and left ventricular EF (LVEF) in HF<br />patients. <br /><strong>Result</strong>: The findings showed no significant connection between<br />CRP and LVEF (p=0.391), implying that CRP does not directly<br />reflect systolic dysfunction. Conversely, IL-6 levels have a<br />substantial inverse connection with LVEF (p=0.001), indicating a<br />greater link between systemic inflammation and cardiac<br />performance. <br /><strong>Conclusion</strong>: These findings underline the importance of a<br />multimodal approach to HF care, including the use of inflammatory<br />markers for risk classification in this population. While CRP may<br />not be as accurate a predictor of systolic dysfunction, IL-6 appears<br />to be more closely related to heart failure severity.</p> <p>Keywords: CRP, Ejection fraction, Heart failure, IL-6.</p> Harvinda Arya Pratiwi Refli Hasan Masrul Lubis Mardianto Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-01 2025-08-01 7 3 115 122 10.32734/jetromi.v7i3.20467 Risk Factors of Type 2 Diabetes Mellitus in Pulmonary Tuberculosis Patients at Prof. Dr. Chairuddin P. Lubis Hospital USU https://talenta.usu.ac.id/jetromi/article/view/20809 <p><strong>Background</strong>: Diabetes mellitus (DM) and tuberculosis (TB) are major global health concerns with a bidirectional relationship that exacerbates clinical outcomes. Indonesia faces a high prevalence of both diseases; however, specific risk factors contributing to the incidence of Type 2 DM (T2DM) among pulmonary TB patients remain underexplored, particularly in North Sumatra. This study aims to identify risk factors associated with T2DMin patients with pulmonary TB.</p> <p><strong>Method:</strong> A retrospective case-control study was conducted involving 80 participants, comprising 40 pulmonary TB patients with T2DM and 40 without DM. Data were obtained from electronic medical records and analyzed using Chi-square tests, Fisher’s Exact Test, and multivariate logistic regression.</p> <p><strong>Result</strong> Educational level (OR = 5.001; p = 0.027), occupational status (OR = 3.500; p = 0.038), and nutritional status based on body mass index (OR = 3.498; p = 0.017) were significantly associated with the incidence of T2DM in pulmonary TB patients.</p> <p><strong>Result:</strong> No significant associations were found for age, gender, radiographic findings, or smoking habits. Higher educational level, employment in the private sector, and having a normal to overweight BMI are key risk factors for T2DM among pulmonary TB patients.</p> Neny Pristiwati Harahap R Lia Kusumawati Noni Novisari Soeroso Santi Syafril Gema Nazri Yanni Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-01 2025-08-01 7 3 123 131 10.32734/jetromi.v7i3.20809 Incidence of Bleeding Complications in Acute ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention https://talenta.usu.ac.id/jetromi/article/view/21143 <table width="100%"> <tbody> <tr> <td width="70%"> <p><strong>Background: </strong>This study aims to comprehensively describe the incidence, types, and associated risk factors of bleeding complications in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), addressing a critical gap in the literature given the global burden of cardiovascular disease and the inherent bleeding risks of contemporary antithrombotic therapies.</p> <p><strong>Methode: </strong>This retrospective cross-sectional study will investigate the incidence and types of bleeding complications, along with associated risk factors, in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) at Adam Malik Hospital Medan, analyzing data from May 2022 to December 2024 through ethical review and statistical analysis using SPSS version 23.</p> <p><strong>Result:&nbsp; </strong>Of 245 STEMI patients undergoing primary PCI, 42.9% experienced bleeding, predominantly minor (BARC 1 and 2, 94.2% combined), with significant associations observed between bleeding and lower hemoglobin, higher leukocyte and creatinine levels, higher TIMI score, Killip class 3 and 4, diabetes, use of maintenance heparin, and increased mortality (84.6% of all deaths occurred in bleeding patients), while hematuria and puncture site hematoma were the most common bleeding sources.</p> <p><strong>Conclusion:&nbsp; </strong>This study found that 42.9% of 245 STEMI patients undergoing primary PCI experienced bleeding complications, predominantly minor (94.2%), with an average age of 55.22 years and a male majority.</p> <p><strong>&nbsp;</strong></p> <p><strong>Keyword:</strong> Bleeding complications, Acute Coronary Syndrome (ACS), ST-Elevation Myocardial Infarction (STEMI), &nbsp;Primary Percutaneous Coronary Intervention (PPCI)</p> </td> </tr> </tbody> </table> Muhammad Ferhat Anggia Chairuddin Lubis Zainal Safri Zulfikri Mukhtar Harris Hasan Teuku Bob Haykal Yasmine Fitrina Siregar Cut Aryfa Andra Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-01 2025-08-01 7 3 132 141 10.32734/jetromi.v7i3.21143 The Association Between The International Society On Thrombosis And Haemostasis- Disseminated Intravascular Coagulation Score And Early Mortality Of Acute Leukemia Patients https://talenta.usu.ac.id/jetromi/article/view/21198 <table> <tbody> <tr> <td> <p><strong>Background</strong>: Disseminated Intravascular Coagulation (DIC) is a serious complication frequently found in patients with acute leukemia and is associated with increased early mortality. The ISTH-DIC score is widely used to assess the severity of DIC. However, data on the association between ISTH-DIC score and early mortality in acute leukemia patients in Indonesia remains limited.</p> <p><strong>Objective:</strong> To evaluate the association between ISTH-DIC score and early mortality (≤60 days) in acute leukemia patients at H. Adam Malik General Hospital, Medan.</p> <p><strong>Methods</strong>: This was a retrospective cohort study involving 68 adult patients diagnosed with acute leukemia admitted from January 2022 to June 2024. Medical records were reviewed to collect laboratory parameters (platelet count, prothrombin time [PT], fibrinogen, and D-dimer) to calculate the ISTH score. Statistical analysis was performed using bivariate and multivariate logistic regression.</p> <p><strong>Results:</strong> The early mortality rate was 58.8%. A substantial proportion of patients had ISTH-DIC scores ≥5, but no statistically significant association was found between ISTH score and early mortality (p = 0.704). However, PT &gt;1.2 seconds was significantly associated with early mortality (p &lt; 0.001; OR 18.00). Platelet count, D-dimer, and fibrinogen levels showed no significant association.</p> <p><strong>Conclusion:</strong> The ISTH-DIC score was not significantly associated with early mortality in acute leukemia patients, but individual components such as prolonged PT showed a strong correlation. Early coagulation assessment remains essential in identifying patients at risk of life-threatening complications.</p> <p>&nbsp;</p> </td> </tr> </tbody> </table> Anita tantri Dairion Gatot Heny Syahrini Lubis Andri Iskandar Mardia Copyright (c) 2025 Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) https://creativecommons.org/licenses/by-nc-sa/4.0 2025-08-01 2025-08-01 7 3 142 148 10.32734/jetromi.v7i3.21198