https://talenta.usu.ac.id/scripta/issue/feed SCRIPTA SCORE Scientific Medical Journal 2022-09-01T09:35:17+07:00 Luthfi Umam Hakim Nasution scripta@usu.ac.id Open Journal Systems <p>SCRIPTA SCORE Scientific Medical Journal is a medical student scientific journal from SCORE PEMA FK USU (Standing Committee on Research Exchange of Student Government Faculty of Medicine, University of North Sumatra). SCRIPTA SCORE Scientific Medical Journal is one of the SCORE PEMA FK USU icons that works together with many reviewers to support the quality and validity of a manuscript. Initially, in 2009, SCORE PEMA FK USU formed a medical student journal with the name of JIMKI (Indonesian Medical Student Scientific Journal). Then for some reason, the management of JIMKI has been moved to BAPIN-ISMKI authority (National Scientific Analysis and Development Agency-Indonesian Medical Student Senate Association). Subsequently, in 2011 a new journal was formed with the name of SCRIPTA by SCORE PEMA FK USU. Since 2016 until now, the SCRIPTA SCORE Scientific Medical Journal was published in 1 volume with 2 numbers every year in February and August that can be accessed <a href="https://drive.google.com/folderview?id=1VmMl2etWqCIEXopvDuGZn6OzSKsyYTk7">here</a>. SCRIPTA SCORE Scientific Medical Journal consists of 5-8 manuscripts with types of manuscripts such as research, literature review, and case reports in each volume. Publications from the SCRIPTA SCORE Scientific Medical Journal can be accessed offline (pISSN <a href="https://portal.issn.org/resource/ISSN-L/2088-8686">2088-8686</a>) on printed SCRIPTA SCORE Scientific Medical Journal magazine or online (eISSN <a href="https://portal.issn.org/resource/ISSN-L/2686-0864">2686-0864</a>) through the SCRIPTA SCORE Scientific Medical Journal (<a href="https://talenta.usu.ac.id/scripta">https://talenta.usu.ac.id/scripta</a>)</p> https://talenta.usu.ac.id/scripta/article/view/8426 Nerve Stimulation: Sebuah Inovasi Terbaru sebagai Alternatif Pengobatan Gangguan Pemusatan Perhatian dan Hiperaktivitas 2022-08-01T16:06:40+07:00 Sherlyn Sean sherlyn.201906000054@student.atmajaya.ac.id Jennifer Rachel Siyulan Jennife.201906000029@student.atmajaya.ac.id Michella Chiara Heriyanto michell.201906000026@student.atmajaya.ac.id Surilena surilena@atmajaya.ac.id <p><strong>Pendahuluan:</strong><span style="font-weight: 400;"> Gangguan pemusatan perhatian dan hiperaktivitas (GPPH) masih menjadi masalah kesehatan jiwa di dunia dan angka kejadian GPPH masih cukup tinggi di Indonesia. Hingga kini, standar regimen yang digunakan adalah farmakoterapi dengan obat golongan psikostimulan yang dinilai kurang baik karena memiliki berbagai efek samping. Sebagai alternatif, terdapat inovasi terbaru, yaitu </span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;">, yang merupakan sebuah prosedur non-invasif dan dapat ditoleransi dengan baik. </span><em><span style="font-weight: 400;">Nerve stimulation</span></em><span style="font-weight: 400;"> dapat dilakukan melalui rangsangan elektrik pada saraf trigeminus (</span><em><span style="font-weight: 400;">Trigeminal Nerve Stimulation</span></em><span style="font-weight: 400;">) dan saraf vagus (</span><em><span style="font-weight: 400;">Vagus Nerve Stimulation</span></em><span style="font-weight: 400;">).&nbsp;</span></p> <p><strong>Tujuan: </strong><span style="font-weight: 400;">Mencari terapi alternatif dengan efektivitas tinggi dan efek samping minimal dalam tatalaksana GPPH.&nbsp;</span></p> <p><strong>Metode:</strong><span style="font-weight: 400;"> Pada </span><em><span style="font-weight: 400;">literature review</span></em><span style="font-weight: 400;"> ini, dilakukan penelusuran kata kunci “</span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;">”, “</span><em><span style="font-weight: 400;">transcutaneous vagus nerve stimulation</span></em><span style="font-weight: 400;">”, “</span><em><span style="font-weight: 400;">trigeminal nerve stimulation</span></em><span style="font-weight: 400;">”, dan “GPPH” melalui beberapa </span><em><span style="font-weight: 400;">search engine</span></em><span style="font-weight: 400;">. Setelah itu, dilanjutkan dengan skrining dimana diperoleh 6 jurnal yang selanjutnya ditinjau secara seksama.</span></p> <p><strong>Pembahasan:</strong><span style="font-weight: 400;"> Pasien dengan GPPH mengalami gangguan regulasi neurotransmitter dimana terdapat penurunan dopamin, GABA dan norepinefrin. Penggunaan </span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;"> dipercaya dapat menjadi terapi efektif untuk pasien GPPH. Uji klinis terhadap </span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;"> pada saraf trigeminus telah menunjukan penurunan nilai ADHD-IV </span><em><span style="font-weight: 400;">Rating Scale</span></em><span style="font-weight: 400;"> dan </span><em><span style="font-weight: 400;">Conners Global Index</span></em><span style="font-weight: 400;">. Stimulasi saraf vagus juga menunjukkan peningkatan produksi neurotransmitter GABA dan norepinefrin dengan cara merangsang beberapa regio di otak terutama </span><em><span style="font-weight: 400;">nucleus tractus solitarius</span></em><span style="font-weight: 400;"> dan </span><em><span style="font-weight: 400;">locus coeruleus</span></em><span style="font-weight: 400;">.</span></p> <p><strong>Kesimpulan:</strong><span style="font-weight: 400;"> Salah satu terapi mutakhir yang dapat digunakan dalam pengobatan GPPH adalah dengan menggunakan alat </span><em><span style="font-weight: 400;">nerve stimulator</span></em><span style="font-weight: 400;">. Secara keseluruhan, </span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;"> memberikan efek yang baik pada pengobatan GPPH. Terapi </span><em><span style="font-weight: 400;">nerve stimulation</span></em><span style="font-weight: 400;"> relatif aman dengan efek samping minimal yang dapat ditoleransi pada mayoritas individu.</span></p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Sherlyn Sean, Jennifer Rachel Siyulan, Michella Chiara Heriyanto, Surilena https://talenta.usu.ac.id/scripta/article/view/8347 Penggunaan SGLT2-i Sebagai Inovasi Terapi Preventif Stroke Pada Pasien Diabetes Mellitus Tipe 2 2022-07-07T15:12:55+07:00 Arya Marganda Simanjuntak arya.marganda@gmail.com Patricia Dean Ully Marbun patriciadeanlly@gmail.com Putri Leony Patresia putrileonyp@gmail.com <p>Diabetes merupakan faktor resiko stroke iskemik sebesar 2,5 kali dan 1,5 kali lipat menderita stroke hemoragik. Hal ini memicu meningkatnya angka mortalitas baik yang disebabkan oleh diabetes, stroke maupun diabetes yang berkomplikasi pada stroke. <em>Sodium Glucose cotransporter 2 inhibitor</em> (SGLT2-i) diketahui dapat mengurangi permasalahan kardiovaskular pada diabetes sehingga penulis akan menelaah lebih lanjut mengenai mekanisme SGLT2-i terhadap vaskular yang dihubungkan terhadap stroke.<em> Literature Review </em>ini dilakukan dengan menelusuri artikel penelitian yang terdapat pada mesin pencarian. Mesin pencarian jurnal yang digunakan berupa <em>PubMed</em> dan <em>Science Direct</em>. Dari 551 artikel diidentifikasi berdasarkan judul, duplikasi, abstrak dan kesesuaian dengan kriteria inklusi dan dilaksanakan <em>review</em> untuk artikel terpilih. SGLT2-i memiliki mekanisme untuk menghambat progresivitas atheroma. Mekanisme yang terjadi berupa penurunan reaksi inflamasi sistemik, penurunan stress oksidatif, pengurangan ukuran ateroma hingga menjaga kestabilan plak ateroma. Oleh karena itu SGLT2-i merupakan kandidat terapi yang potensial dalam mengurangi risiko stroke pada pasien DMT2. SGLT2-i dapat digunakan sebagai inovasi terapi preventif untuk stroke pada pasien DMT2.</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Arya Marganda Simanjuntak, Patricia Dean Ully Marbun, Putri Leony Patresia https://talenta.usu.ac.id/scripta/article/view/8384 The Potential Of Antisense Oligonucleotides (ASO) Through Inhalation Based On Gold Nanoparticle (AuNP) Delivery System In Inhibiting SARS-CoV-2 Replication And Transcription 2022-07-07T13:57:35+07:00 Raehan Satya Deanasa raehansatyad@gmail.com Putri Mahirah Afladhanti mahirah.afladhanti@gmail.com Fara Syafira farasyafira928@gmail.com <p>Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This virus infects the respiratory, digestive, and nervous systems with a rapid transmission and a fairly high mortality rate. However, there has been no specific therapy to treat COVID-19. Previous studies have shown that antisense oligonucleotide (ASO) has good efficacy in DNA and RNA viral infections. This literature review aims to investigate the potential of inhaled ASO based on gold nanoparticles (AuNp) delivery system in inhibiting the replication and transcription of SARS-CoV-2. Literature searching using several databases, such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria are used to eliminate the journals that does not match the criteria, thus 28 journals are obtained. The results show that ASO has the potential to inhibit the replication and transcription of the SARS-CoV-2 virus through different mechanisms by binding to the target RNA and modulating the viral protein synthesis. One form of ASO modification that is often used is LNA GapmeR. LNA GapmeR stimulates viral RNA cleavage and can be administered by inhalation with nebulized ASO solution. AuNP as an ASO delivery system through inhalation can reduce toxicity and increase ASO concentrations in reaching target cells. Therefore, ASO therapy with AuNP through inhalation needs to be considered for COVID-19 treatment. Further clinical study about the ideal delivery system and optimal dosage of ASO based AuNP via inhalation for COVID-19 are needed to investigate soon.</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Raehan, Putri, Fara https://talenta.usu.ac.id/scripta/article/view/8118 Spontaneosus Pneumothorax 2022-07-07T14:57:59+07:00 Abed Nego Okthara Sebayang 1420abednego@gmail.com Setiadi Drajad Kurniawan jadtkv@gmail.com <p><strong>Background</strong>: Pneumothorax is a medical emergency which is defined as an abnormal condition where there is air in the pleural cavity which physiologically contains only a small amount of fluid. Pneumothorax can arise spontaneously or as a result of trauma. <strong>Method</strong>: The method used in this study is a literature review. The literature study conducted by the author is by searching various written sources, whether in the form of books, archives, magazines, articles and journals, or documents that are relevant to the problem being studied. <strong>Discussion</strong>: Pneumothorax is classified as primary spontaneous if it occurs in the absence of basic lung disease or thoracic trauma. Pneumothorax is classified as secondary spontaneous if it is caused by basic lung disease. The etiology of primary spontaneous pneumothorax is pleural bleb and bulla. A bleb (air pocket) or bulla is a small air-filled pocket that forms between the lung and pleural tissues. The risk factors associated with pneumothorax are smoking and body thinness. <strong>Conclusion</strong>: The initial management of <br />spontaneous pneumothorax includes emergency management. Furthermore, management can be divided into conservative and invasive management</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Abed Nego Okthara Sebayang https://talenta.usu.ac.id/scripta/article/view/8392 The Potency of Oral L-Arginine Suplementation Based on Chitosan-Coated Gold Nanoparticles (c-AuNPs) as Preeclampsia Prevention in Pregnant Women 2022-07-08T22:48:29+07:00 Fara Syafira farasyafira928@gmail.com Raehan Satya Deanasa Deanasa raehansatyad@gmail.com Putri Mahirah Afladhanti Afladhanti mahirah.afladhanti@gmail.com <p>Preeclampsia is a multi-systemic hypertensive disorder in pregnant women after two weeks of gestation and can cause complications in about 6-10% of all pregnancies. The incidence of preeclampsia in Indonesia is 128,273/year or about 5.3%. However, the handling of preeclampsia in Indonesia is still not optimal. This disease is difficult to detect and often appears suddenly, so prevention efforts need to be taken as an essential step in reducing morbidity and mortality due to this disease. Previous studies have shown that L-Arginine exhibits potential properties in preventing preeclampsia. This literature review aims to determine the potential for oral L-Arginine supplementation to prevent preeclampsia in pregnant women. Search for literature using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria are used to eliminate unrelated journals so 38 journals are obtained. L-Arginine has great potential as a preventive supplementation of preeclampsia by increasing the vascular NO synthesis where NO deficiency in pregnant women can induce changes in the uteroplacental structure. Supplementation of the dietary L-Arginine at a low dose of 3 g/day for three to four weeks is required in early pregnancy. The use of chitosan-coated gold nanoparticles (c-AuNPs) as encapsulation on a protein increases the bioavailability of oral supplementation and improves the patient's clinical state. Further research regarding the effectiveness of L-Arginine supplementation orally with c-AuNPs and the optimal dosage as a preeclampsia preventive supplement is needed.</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Fara, Raehan, Putri https://talenta.usu.ac.id/scripta/article/view/8361 Identification of Victims Who Have Experienced Advanced Decay 2022-09-01T01:05:57+07:00 asan petrus sembiring asanpetrus95@gmail.com <p><strong><em>Background</em></strong><em>. In the process of investigating a criminal offense, knowing the identity of the victim is something that has a very important meaning, namely as an initial step of the investigation that must be made clear before the next steps can be taken in the investigation process.</em> <strong><em>Objectives. </em></strong><em>to prove that the skeleton is a human skeleton, race, gender, estimated age, height</em><em>.</em><strong><em> Case</em></strong><strong><em> Illustration</em></strong><em>. </em><em>R</em><em>eported cases of a group of bones thought to have originated from human bones. Taken to the hospital to identify who the victim was.</em><strong><em> Discussion</em></strong><em>. Examination found a collection of 196 human bones, in the form of head, neck and the whole body remains bones&nbsp; as well as the right upper limb and lower limb still found skin and muscles that began to dry, blackish brown, foul smelling , a black cocoon (pupa) with a length of 3 cm, and a white maggot (instar I larvae) with a length of 0.5 cm..<strong> Conclusion</strong>. Collection of bones derived from humans, with an estimated Mongoloid race (Asian), male sex, age 15-25 years</em><em>, </em><em>height 157-165 cm, duration of death 10-20 days, with signs of violence in the form of blood infiltration on the left head bone and right skull fracture that extends to the back. the cause of death of the victim is blunt trauma to the head that causes a skull fracture.</em></p> <p><em>&nbsp;</em></p> <p><strong><em>Keywords: Victim Identification, Further Decay</em></strong></p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 asan petrus sembiring https://talenta.usu.ac.id/scripta/article/view/9611 Association between Online Study Stress in COVID-19 Pandemic with Constipation 2022-09-01T09:16:11+07:00 Aqyl Hanif Abdillah aqyl.abdillah@gmail.com <p><strong>Latar Belakang:</strong> Konstipasi sering terjadi dan mempengaruhi 15% populasi di seluruh dunia. Konstipasi dapat menurunkan kualitas hidup pasien dan dapat dipengaruhi oleh banyak faktor, termasuk stres. Stres juga umum, terutama pada siswa, menyebabkan tingkat kecenderungan bunuh diri yang lebih tinggi dan gangguan dari berbagai aspek. Saat ini, di masa pandemi COVID-19, stres lebih sering terjadi karena berbagai penyebab. Salah satu penyebabnya adalah belajar online di masa pandemi COVID-19. <strong>Tujuan:</strong> Untuk mengetahui <br />hubungan antara stres belajar online pada masa pandemi COVID-19 dengan konstipasi pada mahasiswa kedokteran USU angkatan 2018 tahun 2021. <strong>Metode:</strong> Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel dalam penelitian ini adalah 112 mahasiswa kedokteran USU angkatan 2018 yang memenuhi kriteria inklusi dan dikumpulkan dengan menggunakan metode consecutive sampling. Data primer diperoleh dengan menggunakan kuesioner online-shared di google form dan diajukan oleh responden. Kemudian dilakukan analisis univariat dan bivariat pada data menggunakan SPSS, yang <br />terakhir menggunakan Fisher's Exact Test. <strong>Hasil:</strong> Pada penelitian ini 78 siswa (69,6%) mengalami stres dan 8 siswa (7,1%) mengalami konstipasi. Analisis antara kedua variabel menggunakan Fisher's Exact Test menunjukkan nilai p sebesar 0,431, yang dapat diartikan tidak ada hubungan antara stres belajar online pada pandemi COVID-19 dengan konstipasi. Kesimpulan: Stres belajar online pada pandemi COVID-19 tidak terkait dengan sembelit.</p> <p>Kata kunci: Sembelit, Pandemi, Studi Online, Stres</p> <p><strong>Background: </strong>Constipation is common and affects 15% of population worldwide. Constipation can decrease the quality of life of the patients and may be affected by many factors, including stress. Stress too, is general, especially in students, causing higher rates in suicidal tendency and impairments from various aspects. Today, in COVID-19 pandemic, stress is more common due to numerous causes. One of the causes is online studying in COVID-19 pandemic, which might trigger stress in students. <strong>Objectives: </strong>To determine the relationship between online study stress in COVID-19 pandemic with constipation in the year 2018 medical students of USU in 2021. <strong>Method: </strong>This study is an analytical observational study using a cross-sectional design. Samples in this study were 112-year 2018 medical students of USU who satisfied the inclusion criteria and gathered by using a consecutive sampling method. Primary data were acquired by using an online- shared questionnaire in the google form and submitted by the respondents. Then, univariate, and bivariate analyses were performed on the data using SPSS, with the latter using fisher’s exact test. <strong>Results: </strong>In this study, 78 students (69,6%) were stressed and 8 students (7,1%) were constipated. The analysis between the two variables using fisher’s exact test shown the p value about 0,431, which can be interpreted as no association found between online study stress in COVID-19 pandemic with constipation. <strong>Conclusion: </strong>Online study stress in COVID-19 pandemic is not associated with constipation.</p> <p><strong>Keywords: </strong>Constipation, Pandemic, Online study, Stress</p> 2023-01-16T00:00:00+07:00 Copyright (c) 2022 Aqyl Hanif Abdillah https://talenta.usu.ac.id/scripta/article/view/9610 Gambaran Tingkat Pengetahuan Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Tahun 2018 Tentang Inflammatory Bowel Disease 2022-09-01T08:24:32+07:00 Amalia Faghira Aldreyn amalia22_galileo@gmail.com <p><strong>Latar Belakang</strong>: Inflammatory Bowel Disease (IBD) yang terdiri dari Crohn’s Disease dan <br />Ulcerative Colitis dikategorikan sebagai inflamasi usus kronis yang berulang IBD merupakan <br />penyakit yang langka namun angka kejadiannya terus meningkat yang melibatkan adanya interaksi yang kompleks dari genetik, lingkungan atau faktor mikroba dan respons imun. Gejala yang muncul pada penyakit ini biasanya heterogen dan berbahaya. Gambaran klinis juga tergantung pada lokasi penyakit, keparahan peradangan, dan perilaku penyakit. <strong>Tujuan</strong>: Penelitian ini bertujuan untuk mengetahui bagaimana gambaran tingkat pengetahuan mahasiswa Fakultas Kedokteran Universitas Sumatera Utara tahun 2018 tentang IBD. <strong>Metode</strong>: Penelitian yang akan dilakukan adalah penelitian deskriptif observasional menggunakan desain cross sectional dengan teknik pengambilan sampel consecutive sampling. Data diperoleh dari pengisian kuesioner pada 108 sampel mahasiswa Fakultas <br />Kedokteran Universitas Sumatera Utara tahun 2018. <strong>Hasil</strong>: 108 responden yang terdiri dari 31 laki–laki dan 77 perempuan, didapatkan 64 orang dengan tingkat pengetahuan tentang IBD yang kurang, 36 orang dengan tingkat pengetahuan cukup, dan 8 orang berpengetahuan baik. Dijumpai proporsi responden laki – laki dengan tingkat pengetahuan kurang sebanyak 61.3% sementara proporsi responden perempuan sebanyak 58.4%. <strong>Kesimpulan</strong>: Lebih dari setengah dari keseluruhan responden memiliki tingkat pengetahuan tentang IBD yang kurang dengan proporsi tingkat pengetahuan yang kurang dijumpai lebih tinggi pada kelompok jenis kelamin laki – laki daripada perempuan.</p> <p><br /><strong>Kata Kunci</strong>: <em>Crohn’s disease,</em> genetik, i<em>nflammatory bowel disease,</em> respons imun, <em>ulcerative </em><br /><em>colitis</em></p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Amalia Faghira Aldreyn https://talenta.usu.ac.id/scripta/article/view/8867 Knowledge Level of Doctors in USU Medical School Regarding Doctor-Patient Communication 2022-07-07T11:55:25+07:00 Andre Chailes andrechailes.ac@gmail.com T. Ibnu Alferraly tia_mdn2004@yahoo.com <p><strong>Background</strong>. While carrying out its duties, doctors certainly cannot be separated from the act of communicating with patients. Doctor-patient communication is defined as ongoing communication between doctors, as a medic, with the patient as the treated person. This communication skills are important and therefore must be mastered by doctors. But before that, doctors must have adequate knowledge of how to communicate properly and effectively with patients. Lack of this communication skill will be a serious problem so it should not be ignored. <strong>Objective.</strong> To determine the doctors level of knowledge about doctor-patient communication. <strong>Methods.</strong> This study was conducted in descriptive with cross sectional approach. The data were collected by distributing the questionnaire of 15 questions to 71 doctors who were still actively teaching at Faculty of Medicine, Universitas Sumatera Utara. The collected data then analyzed using SPSS computer program. <strong>Results.</strong> The results showed that most of the doctor that work on Faculty of Medicine, Universitas Sumatera Utara, 83.1% of the samples were in good category of knowledge, 14.1% of the samples were in sufficient category of knowledge, the rest 2.8% of the samples were in low category of knowledge. <strong>Conclusion.</strong> Majority of the doctor have a good level of knowledge about doctor-patient communication.</p> <p><strong>Keyword: Communication, Doctor-Patient, Knowledge, Skills</strong></p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Andre Chailes, T. Ibnu Alferraly https://talenta.usu.ac.id/scripta/article/view/8399 Molecular Docking Study of Gingkgo biloba Compounds as Potential Inhibitors of SARS-CoV-2 2022-02-22T23:10:15+07:00 Putri Mahirah Afladhanti Afladhanti mahirah.afladhanti@gmail.com Muhammad Despriansyah Romadhan Romadhan mdespriansyahr@gmail.com Haidar Ali Hamzah Hamzah hah057234@gmail.com Safa Nabila Putri Putri safa.nabila25@gmail.com Ellen Callista Angelica Angelica ellencallista.a@gmail.com <p>COVID-19 pandemic caused by SARS-CoV-2 is a challenge for researchers to find effective drugs for this disease. Previous research had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which were useful as promising drug targets to inhibit SARS-CoV-2. This study aims to identify the potential compounds derived from <em>Ginkgo biloba </em>as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of twenty-one compounds of <em>Ginkgo biloba </em>and comparative drugs were used in this study. The materials were downloaded from rcsb for protein targets and pubchem for comparative drugs and compounds. In this study, Lipinski rule of five using Swiss ADME web tool was used. Moreover, toxicity analysis using admetSAR 2.0 online test also used to predict toxicological profile of compounds. Dockings were carried out on Mpro, TMPRSS2, RdRp, and ACE2 protein targets by AutodockTools 1.5.6 and Autodock Vina. The visualization of molecular interaction was carried out by Discovery Studio v16. Nine compounds met the criteria as drug-like components and were safe. Docking results showed that ginkgolide-C and bilobetin showed strong molecular interactions to all protein targets compared to the comparative drugs and other compounds. In RdRp, ginkgolide-C showed the highest binding energy with -12.7 kcal/mol. Moreover, in TMPRSS2, ACE2 and Mpro, bilobetin also showed the highest binding energy with -12.7, -9.7 and -10 kcal/mol, respectively. Ginkgolide-C and bilobetin have the potential to be developed as SARS-CoV-2 inhibitors. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Putri Mahirah Afladhanti Afladhanti, Muhammad Despriansyah Romadhan Romadhan, Haidar Ali Hamzah Hamzah, Safa Nabila Putri Putri, Ellen Callista Angelica Angelica https://talenta.usu.ac.id/scripta/article/view/9563 Potensi Tepung Ampas Tebu sebagai Bahan Pembuatan Bagasse Biscuits untuk Terapi Konstipasi 2022-08-28T00:07:06+07:00 Putri Chalya Firjatu chalyaaputri@gmail.com Dea Syafira Alamsyah Sitompul deasyafira1212@gmail.com Zahra Arridhani Siregar zahraarridhanisiregar99@gmail.com Shafa Rizki Azzahra shafa368@gmail.com <p style="font-weight: 400;"><strong><em>Background:</em></strong><em> Bagasse is a by-product of the sugarcane process. In Indonesia, bagasse is rarely used as a raw material for making food. Sugarcane bagasse is high in fiber. On the other hand, high rate of constipation in Indonesia requires a high-fiber food product solution. <strong>Objectives:</strong> This study aims to determine whether bagasse flour can be used as an ingredient for Bagasse Biscuits, to find out the level of people's preferences, the nutritional content of Bagasse Biscuits, and its correlation to constipation. <strong>Methods:</strong> This study consisted of three treatments, P1, P2, and P3 respectively at 100%, 50%, and 20% of bagasse flour. The research started by collecting recipes of biscuit literature. The literature is used as a reference to get the right recipe. Before the biscuits are made, the bagasse flour tested in laboratory to determine its nutritional content. Then, the biscuit organoleptic test was carried out to 50 respondents by distributing questionnaires containing assessments of taste, texture, color, and aroma. Furthermore, laboratory tests were conducted on biscuits with the highest organoleptic test values. <strong>Results: </strong>Bagasse flour contains 30.62% carbohydrates, 1.71% protein, 49.51% fiber, and 0.29% fat. Based on the organoleptic test, it was found that respondents preferred Bagasse Biscuits P3 with a taste aspect of 3.96 (delicious), texture 3.12 (soft), color 3.94 (beige chocolate), and aroma 3.96 (strong biscuit aroma). The nutritional content test was carried out on Bagasse Biscuits P3, carbohydrates 11.82%, protein 8.9%, fiber 32.39%, and fat 25.73%. <strong>Conclusion:</strong> bagasse waste which is processed into flour can be used as an ingredient for making Bagasse Biscuits because it contains carbohydrates, protein, fiber, and fat. The fiber content is possible to overcome constipation.</em></p> <p style="font-weight: 400;"><strong><em>Keywords : </em></strong><strong><em>Sugarcane Bagasse</em></strong><strong><em>, </em></strong><strong><em>Biscuits, Constipation </em></strong></p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Putri Chalya Firjatu, Dea Syafira Alamsyah Sitompul, Shafa Rizki Azzahra, Zahra Arridhani Siregar https://talenta.usu.ac.id/scripta/article/view/8373 The Scanographic Profile Of Pancreatic Tumors In 3 Radiology Departments In Kinshasa 2022-09-01T00:32:42+07:00 Molua Antoine recherchepositive@gmail.com Matondo Eric ermatondo@gmail.com Lelo Michel recherchepositive@gmail.com Mukaya Jean recherchepositive@gmail.com Mbongo Angele recherchepositive@gmail.com Yanda Stéphane recherchepositive@gmail.com Bazeboso Bernard recherchepositive@gmail.com Tacite Mazoba tacitemazoba@gmail.com <p><strong>Objective </strong>. Our objective was to describe the scanographic profile of pancreatic tumors in 3 radiology departments in Kinshasa.</p> <p><strong>Methods </strong>. Comparative study conducted in 3 radiology departments in Kinshasa from January 2016 to June 2021, having retained 86 reports of abdominal CT-scans of patients with pancreatic pathology including 62 cases of pancreatic tumors.</p> <p><strong>Results </strong>. Male patients were in the majority (sex-ratio M/F=1.6) with a mean age of 55.7±14.7 years (16 to 92 years). The frequency of pancreatic tumors was higher (62 cases/86) compared to that of inflammatory pathologies (20 cases/86).</p> <p>Cholestasis syndrome (50%) and abdominal (epigastric) pain were the most common indications. In tumors the contours were lobulated (56.1%) compared to pancreatitis, where they were blurred in 80% (p&lt;0.05). In 45% of pancreatitis the peripancreatic fat was infiltrated, against 16.7% in tumors (p=0.01). The Wirsung duct was dilated in most tumors compared to pancreatitis where it was irregular with calcifications (p&lt;0.05). The tumors were resectable in 26% of cases.</p> <p><strong>Conclusion </strong>. The abdominal CT-scan contributes to the diagnosis of pancreatic pathologies. Tumors are the most common, most of them unresectable . It is often an elderly male subject with a clinical indication.</p> 2022-09-01T00:00:00+07:00 Copyright (c) 2022 Tacite Mazoba, eric