Radiotherapy with Neoadjuvant Chemotherapy on Nasopharyngeal Carcinoma (NPC) Advanced Stage

Authors

  • Robertus Suryoseto Radiology Departement, Center General Hospital Persahabatan, Jakarta, Indonesia.

DOI:

https://doi.org/10.32734/ijnpc.v3i01.5576

Keywords:

Nasopharyngeal carcinoma, radiotherapy, radiology

Abstract

Introduction:

Nasopharyngeal carcinoma (NPC) frequently occurs in Indonesia which is endemic to several countries of Asia, specifically in southeastern China, and is associated of infection with Epstein-bar virus (EBV). In recovery, radiation therapy plays a vital role. Chemotherapy will increase the local control rate/disease control rate (DCR) in cases with an advanced local stage.

Case report:

A 49-year-old man felt a lump in his neck accompanied by ringing in his ears and sore throat. Physical examination showed a tumor in the right nasopharynx enlarged into the parapharynx cavity and closed Rosenmuller's fossa. The results of the biopsy were positive for non-keratinized, undifferentiated (WHO-3) type A nasopharyngeal carcinoma (NPC), moderate malignancy. The planned treatment consists of a combination of chemotherapy and radiotherapy. Chemotherapy is given 3 cycles before radiotherapy (neo adjuvant) and 3 cycles of concurrent radiotherapy (adjuvant). The total dose of radiotherapy given was 6,600 c Gy and supra clavicle 5,400 c Gy with fractionation of 33 times in the tumor and 27 times in the supra clavicle. 

Conclusion:

The results presented 6 months after radiotherapy were complete response to loco regional tumors with well tolerated side effects.

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Published

2021-03-20

How to Cite

1.
Suryoseto R. Radiotherapy with Neoadjuvant Chemotherapy on Nasopharyngeal Carcinoma (NPC) Advanced Stage. IJNPC [Internet]. 2021Mar.20 [cited 2021May11];3(01):20-4. Available from: https://talenta.usu.ac.id/IJNPC/article/view/5576