Relationship of Histopathological Grading and Age of HER2-type Breast Cancer Patients at Adam Malik Hospital in January 2022 – June 2024

Authors

  • Giselle Iona Rachel Tuelah Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Heny Syahrini Lubis Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine/Adam Malik Hospital, Universitas Sumatera Utara, Medan, Indonesia
  • Lita Feriyawati Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Feby Yanti Harahap Department of Histology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.32734/scripta.v7i1.20761

Keywords:

breast cancer, HER2, histopathological grading, immunochemistry, molecular subtypes, grading histopatologi, imunohistokimia, kanker payudara, subtipe molekuler

Abstract

Background: Breast cancer is one of the most common cancers that can cause death in Indonesia. Nottingham grading (grade 1, grade 2, and grade 3) in histopathological examination aims to assess tumor activity and prognosis. Other examination includes immunohistochemistry of biomarkers such as estrogen (ER), progesterone (PR), and HER2 receptors. Breast cancer based on its molecular subtypes is classified into luminal A, luminal B, HER2, and triple-negative. HER2-type breast cancer tends to be more invasive with a poor prognosis and susceptible to recurrence and metastasis.

Objectives: This study aims to determine the relationship between histopathological grading and age of patients with HER2-type breast cancer.

Methods: This is a non-experimental analytical research with cross-sectional approach using the total sampling technique. Secondary data were taken from medical records of breast cancer inpatients at Adam Malik Hospital (January 2022 - June 2024) and analysed using Fisher’s exact test. There were 492 inpatient cases of breast cancer, of which 195 were performed an immunohistochemistry examination and 61 cases were HER2-type. The study sample included 54 patients with fulfilled inclusion criteria.

Results: HER2-type breast cancer identified was 31,3%. The most frequent characteristics included female, age ≥45 years, obese nutritional status, and no family history. Poorly differentiated tumors were the most common (38,9%). Result of Fisher’s exact test showed p=0,044 (p<0,05) and OR=0,134.

Conclusion:There is a relationship between histopathological grading and age of patients with HER2-type breast cancer.

Keyword: breast cancer, HER2, histopathological grading, immunochemistry, molecular subtypes

Pendahuluan: Kanker payudara merupakan salah satu jenis kanker yang dapat menyebabkan kematian dan paling sering terjadi di Indonesia. Pemeriksaan histopatologi perlu dilakukan untuk menilai aktivitas tumor dan prognosis. Pemeriksaan lainnya meliputi pemeriksaan imunohistokimia terhadap biomarker seperti reseptor estrogen (ER), progesteron (PR), dan HER2. Kanker payudara tipe HER2 cenderung lebih invasif dengan prognosis yang buruk dan rentan terhadap kekambuhan serta metastasis. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara grading histopatologi dengan usia penderita kanker payudara tipe HER2. Metode: Penelitian ini berjenis analitik non-eksperimental dengan pendekatan cross-sectional yang menggunakan teknik total sampling. Data sekunder diambil dari rekam medis pasien rawat inap kanker payudara di RS. Adam Malik (Januari 2022 – Juni 2024) dan dianalisis menggunakan uji Fisher’s exact. Sampel penelitian ini mencakup 54 pasien yang telah memenuhi kriteria inklusi. Hasil: Kasus kanker payudara yang teridentifikasi tipe HER2 didapati sebesar 31,3%. Karakteristik yang lebih banyak dijumpai meliputi perempuan, usia ≥45 tahun, status gizi mengalami obesitas, dan tanpa riwayat keluarga. Tumor dengan diferensiasi buruk menjadi derajat yang paling banyak ditemukan (38,9%). Hasil uji Fisher’s exact menunjukkan nilai p=0,044 (p<0,05) dan OR=0,134. Kesimpulan: Terdapat hubungan antara grading histopatologi dengan usia penderita kanker payudara tipe HER2.

Kata Kunci: grading histopatologi, HER2, imunohistokimia, kanker payudara, subtipe molekuler

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Published

2025-08-13

How to Cite

1.
Tuelah GIR, Lubis HS, Feriyawati L, Harahap FY. Relationship of Histopathological Grading and Age of HER2-type Breast Cancer Patients at Adam Malik Hospital in January 2022 – June 2024. SCRIPTA SCORE Sci Med J. [Internet]. 2025Aug.13 [cited 2025Aug.20];7(1):50-6. Available from: https://talenta.usu.ac.id/scripta/article/view/20761

Issue

Vol. 7 No. 1 (2025): SCRIPTA SCORE Scientific Medical Journal

Section

Research Article

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Copyright (c) 2025 Giselle Iona Rachel Tuelah, Heny Syahrini Lubis, Lita Feriyawati, Feby Yanti Harahap

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