Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period

Authors

  • Reza Destri Anggi Postgraduate Programs Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Yuandani Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Aminah Dalimunthe Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia

DOI:

https://doi.org/10.32734/idjpcr.v3i2.4311

Abstract

The purpose of the research was to evaluate the teratogenic effect caused by the
provision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml with
positive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. The
measurement parameters in this study are the appearance of reproduction, external
malformations and scalal malformations. The results in this study found that the
administration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /
kg bb caused an abnormality in the reproductive appearance of weight loss and body length,
whereas for extrenal malformation and scalal malforation no abnormalities were found in
each administration of the solution Arabica coffee and caffeine.

 

Downloads

Download data is not yet available.

References

C. P. R. Dubois, “Appendix 2: International Coffee Organization (ICO),” Coffee, pp.

–241.

HAJ. Pohlan, and MJJ. Janssens, “Growth and production of coffee. Dalam Verheye,

W.H (ed). Soils, Plant Growth and Crop Production Volume III”, Nottingham :EOLSS

Publishers. p 5. 2010

M. Nesbitt, H. A. M. van der Vossen, and M. Wessel, “Plant Resources of South-East

Asia no 16. Stimulants,” Kew Bulletin, vol. 55, no. 3, p. 766, 2000.

A. P. Davis, “Two New Species of Coffea L. (Rubiaceae) from Eastern Madagascar,”

Kew Bulletin, vol. 56, no. 2, p. 479, 2001.

M. Kleinwächter, G. Bytof, and D. Selmar, “Coffee Beans and Processing,” Coffee in

Health and Disease Prevention, pp. 73–81, 2015.

A. P. Craig, A. S. Franca, L. S. Oliveira, J. Irudayaraj, and K. Ileleji, “Fourier transform

infrared spectroscopy and near infrared spectroscopy for the quantification of defects in

roasted coffees,” Talanta, vol. 134, pp. 379–386, Mar. 2015.

R. M. N. de Souza, G. A. B. Canuto, R. C. E. Dias, and M. de T. Benassi, “Teores de

compostos bioativos em cafés torrados e moídos comerciais,” Química Nova, vol. 33, no.

, pp. 885–890, 2010.

A. S. Franca, L. S. Oliveira, R. C. S. Oliveira, P. C. M. Agresti, and R. Augusti, “A

preliminary evaluation of the effect of processing temperature on coffee roasting degree

assessment,” Journal of Food Engineering, vol. 92, no. 3, pp. 345–352, Jun. 2009.

F. Wei and M. Tanokura, “Chemical Changes in the Components of Coffee Beans during

Roasting,” Coffee in Health and Disease Prevention, pp. 83–91, 2015.

A. Farah, “Coffee :Emerging Health Effects and Disease Prevention, First Edition”, John

Willey & Sons, Inc and Institute of Food Technologists (USA): Wiley-Blackwell

Publising Ltd. 2012

S. Oestreich, S. and Janzen, Chemistry of Coffee. CAFEA GmbH, Hamburg,

Germany:Elsevier Ltd, p. 10. 2010

C. D. Frary, R. K. Johnson, and M. Q. Wang, “Food sources and intakes of caffeine in the

diets of persons in the United States,” Journal of the American Dietetic Association, vol.

, no. 1, pp. 110–113, Jan. 2005.

J. J. Barone and H. R. Roberts, “Caffeine consumption,” Food and Chemical Toxicology,

vol. 34, no. 1, pp. 119–129, Jan. 1996.

World Health Organization (WHO). Infant Mortality Rate. WHO, 2012.

J. J. Barone and H. R. Roberts, “Caffeine consumption,” Food and Chemical Toxicology,

vol. 34, no. 1, pp. 119–129, Jan. 1996

M. Bhara, “Pengaruh Pemberian Kopi Dosis Bertingkat Per Oral 30 Hari terhadap

Gambaran Histologi Hepar Tikus Wistar”, Laporan Akhir Karya Tulis Ilmiah. Semarang:

Universitas Diponegoro, 2009

A. Burger, “Evaluation of Drug Activities: Pharmacometrics.,” Journal of Medicinal

Chemistry, vol. 9, no. 3, pp. 452–452, May 1966.

FW. Ganong, F, “Review of Medical Physiology, and Canine and Feline Endocrinology

and Reproduction”, Penerbit EGC. Jakarta.1989

K. Nomura, S. Saito, K. Ide, Y. Kamino, H. Sasahara, T. Nakamoto, and Y.

Abiko, “Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell

culture and rat placenta,” The Journal of Nutritional Biochemistry, vol. 15, no. 6,

pp. 342–349, Jun. 2004.

B. Clausson, “Effect of Caffeine Exposure during Pregnancy on Birth Weight and

Gestational Age,” American Journal of Epidemiology, vol. 155, no. 5, pp. 429–

, Mar. 2002.

J. Pozner, “Association of tumor differentiation with caffeine and coffee intake in

women with breast cancer,” Plastic and Reconstructive Surgery, vol. 79, no. 5, p.

, May 1987.

Published

2021-01-14

How to Cite

Reza Destri Anggi, Yuandani, & Dalimunthe, A. (2021). Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period. Indonesian Journal of Pharmaceutical and Clinical Research, 3(2), 25-31. https://doi.org/10.32734/idjpcr.v3i2.4311

Most read articles by the same author(s)