Breast Cancer Clinicopathology based on Neutrophil Levels at Adam Malik Hospital Medan in 2018-2021

Authors

  • Tonggo Mario Saragih Undergraduate Program of Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Dedy Hermansyah Departement of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Denny Rifsal Siregar Departement of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Dina Aprillia Ariestine Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia

DOI:

https://doi.org/10.32734/sumej.v7i1.10946

Keywords:

breast cancer, clinicopathology, neutrophil levels, prognostic factors

Abstract

Background: Breast cancer is the most frequently diagnosed cancer in the world. Breast cancer occurs due to abnormal cell growth in breast tissue so that it becomes malignant. In Indonesia, breast cancer is the most common cancer in women. That way, many markers are needed as prognostic and predictive of breast cancer. One of the prognostic factors for breast cancer is neutrophil levels combined with clinicopathological factors. Objective: Knowing the clinicopathology of breast cancer based on neutrophil levels at the Adam Malik Medan General Hospital in 2018-2021. Methods: The research design is observational with a descriptive method and calculated using the Lemeshow formula. Results: Majority aged 40-49 years (39.6%), high school (44.8%), housewives (67.7%), no family history (97.9%), tumor grade II (38.5%) %), Tumor Infiltrating Lymphocytes (TILs) severe (47.9 %), mitotic score 1 (38.5 %), metastatic positive lymph node status (87.5 %), tumor size T1 (36.5 %), The number of positive and negative Estrogen Receptors is the same (50.0%), Progesterone Receptor is negative (56.3%), HER2 is 1+ (60.4%), Ki-67 is positive (84 .4 %), positive angioinvasion (63.5 %), Invasive Ductal Carcinoma (90.6 %), high neutrophil levels (77.1 %). Conclusion: High levels of neutrophils tend to result in severe Tumor Infiltrating Lymphocytes (TILs) which will increase tumor growth, occurrence of metastases, increased positive angioinvasion, negative Estrogen Receptor status, negative Progesterone Receptor status, HER2 1+ status, positive Ki-67 status.

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Published

2024-01-01

How to Cite

1.
Mario Saragih T, Hermansyah D, Rifsal Siregar D, Aprillia Ariestine D. Breast Cancer Clinicopathology based on Neutrophil Levels at Adam Malik Hospital Medan in 2018-2021. Sumat. Med. J. [Internet]. 2024Jan.1 [cited 2025May12];7(1):7-13. Available from: https://talenta.usu.ac.id/smj/article/view/10946

Issue

Vol. 7 No. 1 (2024): Sumatera Medical Journal (SUMEJ)

Section

Research Article

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