Equianalgesic Oxycodone, Continuous Intravenous Morphine in Post- Long Bone Surgery
DOI:
https://doi.org/10.32734/sumej.v2i3.1240Keywords:
Oxycodone, Morphine, Opiates, Visual Analogue Score, Equianalgesic DoseAbstract
Oxycodone and morphine are powerful analgesic drugs used for post-operative pain management. There is no studies have been conducted to assess the dose equivalency between the two drugs. To get an equianalgesic dose of Oxycodone and Morphine. This study was using a double-blind randomized clinical trials, 48 samples, ages 21-60 years, PS ASA I-II, which will get an elective orthopedic surgery using general anesthesia tech-niques. Oxycodone (group A) : Morphine (group B) (Initial 5mg than continuous 1 mg/hour : initial dose 4mg than continuous 0,5 mg/hour). Average drug dose for group that takes morphine and oxycodone (3.90 ± 0.46 mg : 1.46 ± 0.51 mg). No significant difference between the average dose (p <0.05). Equianalgesic dosein group Oxycodone and Morphine is 1.4 mg: 3.9mg.
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References
Morgan GE, Mikhail MS, Murray MJ. Perioperative pain managament &enhanched outcomes. In: Clinical anesthesiology, 5th ed. Lange Medical Books/McGraw-Hill, 2013: 1087-105.
Rawal N, Fischer HBJ, Ivani G, et al. Postoperative pain management – good clinical practice. European Society of Regional Anestesi. Sweden, 2008.
Stoelting RK, Hillier SC. Pain. In: Pharmacology &physiology in anesthetic practice, 4th ed. Lippincott Williams & Wilkins, 2006: 707-17.
Misiolek H, Cettler M, Woron J, et al. The 2014 Guidelines For Post-Operative Pain Management. 2014.
Plante GE, VanItallie TB. Metabolism Clinical and Experimental . 2010: 59 (Suppl 1): S47–S52
OxyNorm® solution for injection or infusion 10mg/mL PI. Mundipharma Pty Ltd, Sydney, NSW. 23 Dec 2015.
Silvasti M, Tarkkila P, Tuominen M et al (1999) Efficacy and side effects of tramadol versus oxycodone for patientâ€controlled analgesia after maxillofacial surgery. Eur J Anaesthesiol 16(12): 834–9.
Lenz Harald, Sandvik Leiv, Qvigstad Erik, dkk. A Comparison of Intravenous Oxycodone and Intravenous Morphine in Patient-Controlled Postoperative Analgesia After Laparoscopic Hysterectomy. International Anesthesia Research Society. 2009: 109(4): 1279-1283
Sommer M, de Rijke JM, van Kleef M, Kessels AG, Peters ML, GeurtsJW et al. The prevalence of postoperative pain in a sample of 1490 surgical inpatient. Eur J Anaesthesiol, 2008; 25: 267-74
Jane, C. Ballantyne.,2008. Acute Pain Management. In: Longnecker D, Brwon D, Newman M, Zapol W. Anesthesiology. USA. The McGraw-Hill Companies. pp. 1743-63.
Kalso E, Sarella MV, et all. The Compassionate Brain : human detect of pain from another’s face. Cereb Cortex. 2007 Jan; 17(1): 230-7.
Eastern Metropolitan Regio Palliative Care Consortium. Opioid Conversion Ratios : Guideline to Practice. Melbourne. 2010, www.emrpcc.org.au/wp- content/uploads/2013/03/EMRPCC-Opioid-Conversion2010-Final2.pdf (Accessed: February, 2017)
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