Determination of Dexamethasone in Unregistered Herbal Weight Gain Using HPTLC-Densitometry

Authors

  • Ridho Asra SEKOLAH TINGGI ILMU FARMASI (STIFARM) PADANG http://orcid.org/0000-0002-5402-3764
  • Zulharmita SEKOLAH TINGGI ILMU FARMASI (STIFARM) PADANG
  • Nopitri Yuliatim SEKOLAH TINGGI ILMU FARMASI (STIFARM) PADANG

DOI:

https://doi.org/10.32734/idjpcr.v1i2.331

Keywords:

Dexamethasone, Herbal, HPTLC-Densitometry, Weight Gain

Abstract

A method was described for the simultaneous determination of dexamethasone in herbal weight gain. Three unregistered herbal weight gains (sample A, B, and C) were analyzed by using HPTLC-densitometry method. Samples were extracted as bases into methanol, separated by HPTLC silica gel 60 F254plate using chloroform: methanol (9:1) as mobile phase followed by densitometry measurement of its spot. The result showed that the detector response was linear for concentrations between 100-500 mg/mL (r =0.998). The limits of detection and quantitation were 9.19 mg/mL and 30.64 mg/mL, respectively. Dexamethasone contents from samples were analyzed. The result showed that two samples (sample A and B) were positively containing dexamethasone and the other one showed a negative result. The average contents of dexamethasone from both samples were 0.23% and 0.25%, respectively.

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Published

2018-12-31

How to Cite

Asra, R., Zulharmita, & Yuliatim, N. (2018). Determination of Dexamethasone in Unregistered Herbal Weight Gain Using HPTLC-Densitometry. Indonesian Journal of Pharmaceutical and Clinical Research, 1(2), 21-28. https://doi.org/10.32734/idjpcr.v1i2.331

Issue

Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research

Section

Articles

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