Plasma Sirt-1 Level in Various Frailty Degree in Elderly Outpatients at Prof. Chairudin P. Lubis Hospital, Medan

Fadhilah Hayati; Dedi Ardinata; Nuraiza Meutia; Ririe Fachrina Malisie; Muhammad Ichwan

doi:10.32734/ijoep.v5i2.13681

Authors

Fadhilah Hayati Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Sumatera Utara
Dedi Ardinata Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara
Nuraiza Meutia Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara
Ririe Fachrina Malisie Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara
Muhammad Ichwan Departments of Pharmacology & Therapeutics, Faculty of Medicine, Universitas Sumatera Utara

DOI:

https://doi.org/10.32734/ijoep.v5i2.13681

Keywords:

Frailty, Sirt1, Polymorphism (rs2273773), Elderly, Physical Aging

Abstract

Frailty is a physical aging syndrome characterized by health vulnerability. Diagnosis is established incorrectly based on three or more of the five criteria: weakness, decreased walking speed, fatigue, decreased physical activity, and weight loss. Sirtuin 1 plays a role in weakness, particularly in the elderly, acting as a protective factor during weakness, and its activation could provide a novel therapeutic approach. However, research in this area is still very limited. A cross-sectional method with observation or measurement of study subjects was employed in this research, involving a total of 118 elderly subjects selected through non-probability sampling. Pearson correlation test indicates a relationship between the polymorphism genotype (rs2273773) in the SIRT1 gene and the frailty scale (p-value < 0.05), while no relationship was found between plasma SIRT1 levels and the frailty scale (p-value > 0.05). Furthermore, the F-test reveals a significant simultaneous relationship between the polymorphism genotype (rs2273773) and plasma SIRT1 levels with frailty (p-value < 0.05).