Antioxidative and Apoptotic Activities of Vernonia amygdalina Ethanolic Extract in the AOM/DSS Mice Model of Colon Cancer
DOI:
https://doi.org/10.32734/ijoep.v6i2.17290Keywords:
Antioxidants, AOM/DSS, Apoptosis, VAEE, Colon CancerAbstract
This study examined the efficacy and safety of Vernonia amygdalina ethanol extract (VAEE) therapy in treating azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colon cancer in mice, aiming to uncover the underlying mechanisms. A colon cancer mice model was used to evaluate the effects of VAEE on antioxidant enzyme levels and apoptosis. VAEE treatment increased SOD and caspase-3 levels while reducing MDA and Bcl-2 levels. These results indicate the potential of VAEE as an anticancer agent, with several doses showing significant increases in SOD and caspase-3 levels while significantly reducing MDA and Bcl-2 levels compared to the negative control (p<0.05). A dose of 500 mg/kg BW appears to be a potential candidate anticancer agent. Further studies on the molecular mechanisms and long-term effects are needed to support clinical applications.
Keywords: Antioxidants, AOM/DSS, Apoptosis, VAEE, Colon Cancer
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- 2024-09-29 (2)
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