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Antioxidative and Apoptotic Activities of Vernonia amygdalina Ethanolic Extract in the AOM/DSS Mice Model of Colon Cancer

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DOI:

https://doi.org/10.32734/ijoep.v6i2.17290

Keywords:

Antioxidants, AOM/DSS, Apoptosis, VAEE, Colon Cancer

Abstract

This study examined the efficacy and safety of Vernonia amygdalina ethanol extract (VAEE) therapy in treating azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colon cancer in mice, aiming to uncover the underlying mechanisms. A colon cancer mice model was used to evaluate the effects of VAEE on antioxidant enzyme levels and apoptosis. VAEE treatment increased SOD and caspase-3 levels while reducing MDA and Bcl-2 levels. These results indicate the potential of VAEE as an anticancer agent, with several doses showing significant increases in SOD and caspase-3 levels while significantly reducing MDA and Bcl-2 levels compared to the negative control (p<0.05). A dose of 500 mg/kg BW appears to be a potential candidate anticancer agent. Further studies on the molecular mechanisms and long-term effects are needed to support clinical applications.

Keywords: Antioxidants, AOM/DSS, Apoptosis, VAEE, Colon Cancer

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Published

2024-09-27

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How to Cite

Said Aldi Palevi, Hasibuan, P. A. Z. ., & satria, denny. (2024). Antioxidative and Apoptotic Activities of Vernonia amygdalina Ethanolic Extract in the AOM/DSS Mice Model of Colon Cancer. International Journal of Ecophysiology, 6(2), 26-34. https://doi.org/10.32734/ijoep.v6i2.17290