Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus)

Authors

  • Suresh Mani Department of Physiotherapy, School of Applied Medical Sciences, Lovely Profesional University, Punjab, 144402, India
  • Ratna Akbari Ganie Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Dina Keumala Sari Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia
  • Liza Meutia Sari Department of Oral Medicine, Faculty of Dentistry, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia
  • Meike Rachmawati Department of Anatomical Pathology, Faculty of Medicine, Universitas Islam Bandung, Bandung, 40116, Indonesia
  • Noorzaid Muhammad Department of Integrative Physiology and Molecular Medicine, Faculty of Medicine, Royal College of Medicine, Universitas Kuala Lumpur, Perak, 30450, Malaysia

DOI:

https://doi.org/10.32734/sumej.v6i2.11931

Keywords:

antioxidant, flower, inflammation, phytochemicals, rat, remembrance

Abstract

Background: The inflammatory process is influenced by chemical mediators such as Nitric Oxide (NO), cytokines, and arachidonic acid metabolites. The therapeutic effect of herbal plants comes from phytochemicals with strong antioxidant activity. Objective: To examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This was a two-stage study: in vitro and in vivo. Anti-inflammatory activity is related not only to antioxidant properties but also to suppression of nitric oxide and pro-inflammatory cytokines. This effect is being explored using various herbal plants. One such plant is Cananga odorata (ylang flower), a tropical plant with fragrant petals that grows easily. Results: The total phenol content was 1.06% w/w. Antioxidant activity measured using DPPH method showed an IC50 of 808.86 ppm, indicating weak antioxidant activity. In rats, the extract reduced blood glucose levels but had no effect on lipid profiles. Toxicity testing showed no toxic effects. Histological analysis showed no differences between cardiovascular disease model mice and standard-fed mice. Conclusion: The ethanol extract of Cananga odorata did not show toxicity in the heart histopathology of white rats.

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References

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Published

2023-05-15

How to Cite

1.
Mani S, Akbari Ganie R, Keumala Sari D, Meutia Sari L, Rachmawati M, Muhammad N. Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus). Sumat. Med. J. [Internet]. 2023May15 [cited 2025Apr.27];6(2):84-9. Available from: https://talenta.usu.ac.id/smj/article/view/11931

Issue

Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)

Section

Research Article

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