Subaccute Toxicity Yellow Flower Extract (Cananga Odorata) on Histopathology of White Rat Heart (Rattus Norvegicus)
DOI:
https://doi.org/10.32734/sumej.v6i2.11931Keywords:
Antioxidant, Flower, Inflammation, Phytochemicals, Remembrance, RatAbstract
Abstract.
Introduction: The inflammatory process is influenced by chemical mediators such as nitric oxide (NO), cytokines, and arachidonic acid metabolites. Currently, herbal treatment techniques are preferred by the public because they generally do not cause side effects. The therapeutic effect of herbal plants comes from the content of phytochemicals that have strong antioxidant activity. Objective: Objective of the study was to examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This research is a two-stage research, namely in vitro and in vivo tests. Many previous studies have proven that anti-inflammatory activity is not only related to antioxidant activity but also its ability to suppress the production of nitric oxide and pro-inflammatory cytokines. This effect is still being developed using a variety of herbal plants. One of the plants whose effects have not been studied in the field of health-medicine is ylang flower. Cananga odorata (Annonaceae) or ylang flower plant is a tropical plant that has fragrant petals and thrives without requiring special care. Results: Results of the study were total phenol 1,06 %w/w and antioxidant IC50 DPPH by spectrophotometric examination was 808.86 ppm. These results do not show good antioxidant activity of ylang flower extract. Research in rats showed a decrease in blood glucose levels but not in lipid profiles. Furthermore, the toxicity test did not show any toxicity in experimental rats. Histological appearances showed no differences in cardiovascular disease model mice with standard-feeding mice. Conclusions: Cananga odorata ethanol extract did not showed any toxicity on histopatology on white rat heart.
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Jin J, Kim MJ, Dhandapani S, et al. The floral transcriptome of ylang ylang (Cananga odorata var. fruticosa) uncovers biosynthetic pathways for volatile organic compounds and a multifunctional and novel sesquiterpene synthase. J Exp Bot 2015;66(13):3959–75.
Lee K, Lee JH, Kim SI, Cho MH, Lee J. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol 2014;98(22):9447–57.
Matsumoto T, Nakamura S, Fujimoto K, et al. Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase. J Nat Med 2014;68(4):709–16.
Matsumoto T, Nakamura S, Nakashima S, et al. Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis. J Nat Prod 2014;77(4):990–9.
Zhang X, Herger AG, Ren Z, Li X, Cui Z. Resistance effect of flavonols and toxicology analysis of hexabromocyclododecane based on soil-microbe-plant system. Chemosphere 2020;257:127248.
Phatchana R, Thongsri Y, Yenjai C. Canangalias C-H, juvenile hormone III analogues from the roots of Cananga latifolia. Fitoterapia 2016;114:45–50.
Qin XW, Hao CY, He SZ, et al. Volatile organic compound emissions from different stages of Cananga odorata flower development. Molecules 2014;19(7):8965–80.
Soonwera M. Efficacy of essential oil from Cananga odorata (Lamk.) Hook.f. & Thomson (Annonaceae) against three mosquito species Aedes aegypti (L.), Anopheles dirus (Peyton and Harrison), and Culex quinquefasciatus (Say). Parasitol Res 2015;114(12):4531–43.
Tan LT, Lee LH, Yin WF, et al. Traditional Uses, Phytochemistry, and Bioactivities of Cananga odorata (Ylang-Ylang). Evid Based Complement Alternat Med 2015;2015:896314.
Liu C, Wu H, Wang L, et al. Farfarae Flos: A review of botany, traditional uses, phytochemistry, pharmacology, and toxicology. J Ethnopharmacol 2020:113038.
Benini C, Mahy G, Bizoux JP, et al. Comparative chemical and molecular variability of Cananga odorata (Lam.) Hook.f. & Thomson forma genuina (ylang-ylang) in the Western Indian Ocean Islands: implication for valorization. Chem Biodivers 2012;9(7):1389–402.
Neumann NR, Thompson TM. Medical Toxicology Education and Global Health: It is Still a World of Limited Resources in Low- and Middle-Income Countries. J Med Toxicol 2020.
Yang H, Kim HS, Jeong EJ, et al. Plant-derived juvenile hormone III analogues and other sesquiterpenes from the stem bark of Cananga latifolia. Phytochemistry 2013;94:277–83.
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