Revolutionizing Herbal Medicine: Exploring Nano Drug Delivery Systems
DOI:
https://doi.org/10.32734/sumej.v6i3.12799Keywords:
Revolutionizing, Herbal medicine, Nano drug delivery systems, Bioavailability, Stability, Nanotechnology, Nanocarriers, Liposomes, Polymeric nanoparticles, Solid lipid nanoparticles, NanoemulsionsAbstract
Abstract.
Introduction: Traditional herbal medicine has been practiced for centuries and continues to play a significant role in healthcare systems worldwide. However, the efficacy and therapeutic potential of herbal remedies can be limited due to various factors such as poor bioavailability, instability, and non-specific targeting. In recent years, nanotechnology has emerged as a promising approach to overcome these limitations and revolutionize the field of herbal medicine. This review explores the application of nano drug delivery systems in enhancing the effectiveness of herbal therapeutics. The utilization of nanotechnology in the context of herbal medicine involves the design and development of nano-sized carriers that can encapsulate and deliver herbal bioactive compounds to the target sites in a controlled and targeted manner. Various types of nanocarriers, such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, and nanoemulsions, have been extensively investigated for their potential in improving the bioavailability, stability, and controlled release of herbal compounds. The integration of nanotechnology with herbal medicine offers several advantages, including enhanced solubility, protection against degradation, prolonged circulation time, and specific targeting to diseased tissues or cells. Furthermore, nano drug delivery systems can also facilitate the combination of multiple herbal ingredients, enabling synergistic effects and customized therapeutic approaches. This review provides an overview of the recent advancements in nano drug delivery systems for herbal medicine, highlighting their potential applications in various therapeutic areas, such as cancer treatment, neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions. Additionally, challenges and future perspectives regarding the clinical translation of these nanotechnological approaches are discussed. In conclusion, the integration of nanotechnology with herbal medicine holds great promise in revolutionizing the field of healthcare. The development of efficient and targeted nano drug delivery systems can significantly enhance the therapeutic efficacy of herbal remedies, leading to improved patient outcomes and the potential for personalized medicine. Further research and collaborations between scientists, herbalists, and clinicians are needed to unlock the full potential of nano drug delivery systems in herbal medicine.
Keywords: Revolutionizing, Herbal medicine, Nano drug delivery systems, Bioavailability, Stability, Nanotechnology, Nanocarriers, Liposomes, Polymeric nanoparticles, Solid lipid nanoparticles, Nanoemulsions
Downloads
References
Prabhakar, Pranav K., and Mukesh Doble. "A target based therapeutic approach towards diabetes mellitus using medicinal plants." Current Diabetes Reviews, Vol 4, no. 4, pp. 291-308, 2008.
Kumar Prabhakar, Pranav, Swetha Vijayaraghavan, John Philip, and Mukesh Doble. "Biocompatibility studies of functionalized CoFe2O4 magnetic nanoparticles." Current Nanoscience, Vol 7, no. 3, pp. 371-376, 2011.
Pathak, Chandramani, Foram U. Vaidya, and Shashibhal M. Pandey. "Mechanism for development of nanobased drug delivery system." Applications of targeted nano drugs and delivery systems, pp. 35-67, 2019.
Darul Raiyaan, G. I., A. Sameera Khathoon, and Kantha D. Arunachalam. "Nutrients Delivery for Management and Prevention of Diseases." Advances in Novel Formulations for Drug Delivery, pp. 491-519, 2019.
Bahloul, Badr, Luis Castillo-HenrÃquez, Latifa Jenhani, Nebras Aroua, Mahdi Ftouh, Nesrine Kalboussi, José Vega-Baudrit, and Nathalie Mignet. "Nanomedicine-based potential phyto-drug delivery systems for diabetes." Journal of Drug Delivery Science and Technology, 104377, 2023.
Muzammil, Saima, Aliza Mazhar, Derya KarataÅŸ Yeni, Rahat Andleeb, Asma Ashraf, Mirza Imran Shehzad, Nimrah Zafar, and Maryam Mazhar. "Nanospanlastic as a promising nanovesicle for drug delivery." In Systems of Nanovesicular Drug Delivery, pp. 337-352. Academic Press, 2022.
Souri, Mohammad, M. Soltani, Farshad Moradi Kashkooli, and Mohammad Kiani Shahvandi. "Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles." Journal of Controlled Release, Vol. 341, pp. 227-246, 2022.
Torchilin, V. P. Recent advances with liposomes as pharmaceutical carriers.†Nature Reviews Drug Discovery, Vol. 4, no. 2, pp. 145-160, 2005.
Bhalekar, M. R., Upadhaya, P., Madgulkar, A. R., & Madgulkar, A. â€Liposomal drug delivery system from laboratory to clinic. Journal of Drug Delivery Science and Technology, Vol. 41, pp. 355-367, 2017.
Sawant, R. R., Torchilin, V. P., & Siegel, B. A. “Targeted delivery of small interfering RNA with cell surface receptor-targeted, dual-functional liposomes.†International Journal of Pharmaceutics, Vol. 466, no. 1-2, pp. 327-335, 2014.
Sharma, A., Sharma, U. S., & Straubinger, R. M. “Liposomes in drug delivery: Progress and limitations.†International Journal of Pharmaceutics, Vol. 364, no. 2, pp. 2-15, 2007.
Allen, T. M., & Cullis, P. R. “Liposomal drug delivery systems: From concept to clinical applications.†Advanced Drug Delivery Reviews, Vol. 65, no. 1, pp. 36-48, 2013.
Sharma, G., Sharma, A. R., Nam, J. S., Doss, G. P., Lee, S. S., & Chakraborty, C. “Nanoparticle based insulin delivery system: The next generation efficient therapy for Type 1 diabetes.†Journal of Nanobiotechnology, Vol. 13, no. 1, pp. 74, 2015.
Kumari, A., Yadav, S. K., & Yadav, S. C. “Biodegradable polymeric nanoparticles based drug delivery systems.†Colloids and Surfaces B: Biointerfaces, Vol. 75, no. 1, pp. 1-18, 2010.
Jain, S., Patel, N., Shah, M. K., & Khatri, P. “Polymeric nanoparticles: Promising platform for drug delivery.†Current Drug Delivery, Vol. 13, no. 8, pp. 1290-1305, 2016.
Jain, K., & Kesharwani, P. “Polymeric nanoparticles for drug delivery and targeting: A comprehensive review.†Journal of Drug Delivery Science and Technology, Vol. 32, pp. 101-164, 2016.
Gupta, A., Eral, H. B., Hatton, T. A., & Doyle, P. S. “Nanoemulsions: Formation, properties and applications.†Soft Matter, Vol. 12, no. 11, pp. 2826-2841, 2016.
Svenson, S., & Tomalia, D. A. “Dendrimers in biomedical applications—reflections on the field.†Advanced Drug Delivery Reviews, Vol. 57, no. 15, pp. 2106-2129, 2005.
Menjoge, Anupa R., Rangaramanujam M. Kannan, and Donald A. Tomalia. "Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications." Drug discovery today Vol. 15, no. 5-6, pp. 171-185, 2010.
Bhadra, D., S. Bhadra, and N. K. Jain. "PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate." Pharmaceutical research Vol. 23 pp. 623-633, 2006.
Svenson, S., & Tomalia, D. A “Dendrimers in biomedical applications—reflections on the field.†Advanced Drug Delivery Reviews, Vol. 64, pp. 102-115, 2012.
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., & Weener, J. W. “Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.†Journal of Controlled Release, Vol. 65, no. 1-2, pp. 133-148, 2000.
Pantarotto, D., Briand, J. P., & Prato, M. “Translocation of bioactive peptides across cell membranes by carbon nanotubes.†Chemical Communications, Vol. 1, pp. 16-17, 2004.
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El-Sayed, M. A. “The golden age: gold nanoparticles for biomedicine.†Chemical Society Reviews, Vol. 41, no. 7, pp. 2740-2779, 2012.
Lawrence, M. J., & Rees, G. D. “Microemulsion-based media as novel drug delivery systems.†Advanced Drug Delivery Reviews, Vol. 64, pp/ 175-193, 2012.
Li, J., Mooney, D. J., & Pelton, R. “Nanosponges as a versatile platform for drug delivery and biomedical applications.†Advanced Materials, Vol. 28, no. 37, pp. 8205-8228, 2016.
Merisko-Liversidge, E., & Liversidge, G. G. “Nanosizing for oral and parenteral drug delivery: A perspective on formulating poorly-water soluble compounds using wet media milling technology.†Advanced Drug Delivery Reviews, Vol. 63, no. 6, pp. 427-440, 2011.
Silva, A. L., Rosalia, R. A., Sazak, A., Carstens, M. G., Ossendorp, F., & Oostendorp, J. “Protein encapsulation in biodegradable nanoparticles for antigen delivery: A review.†Journal of Controlled Release, Vol. 217, pp. 154-163, 2015.
Nel, Andre, Tian Xia, Lutz Madler, and Ning Li. “Toxic potential of materials at the nanolevel.†Science, Vol. 311, no. 5761, pp. 622-627, 2006.
Magdolenova, Z., Collins, A., Kumar, A., Dhawan, A., Stone, V., & Dusinska, M. “Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles.†Nanotoxicology, Vol. 8, no. 3, pp. 233-278, 2014.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Sumatera Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Sumatera Medical Journal (SUMEJ) and Faculty of Medicine as well as TALENTA Publisher Universitas Sumatera Utara as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Sumatera Medical Journal (SUMEJ).
The Copyright Transfer Form can be downloaded here.
The copyright form should be signed originally and sent to the Editorial Office in the form of original mail or scanned document.