PREVALENCE AND CHARACTERISTICS OF BREAST CANCER IN YOUNG WOMEN

Authors

  • Denny Rifsal Siregar Faculty Of Medicine, Universitas Sumatera Utara
  • Andreas Christoper Faculty of Medicine USU

Keywords:

Young Age Breast Cancer, Stage, Histopathological Type, Grade, Clinical Subtype

Abstract

Breast cancer is a major health problem for women. This cancer is most often diagnosed and the leading cause of cancer deaths in women worldwide. Breast cancer in young women is associated with late diagnosis, aggressive biological characteristics, and poor prognosis. The objective of the study is to determine the prevalence and characteristics of young age breast cancer in Haji Adam Malik General Hospital Medan in 2013-2017. The study design was observational descriptive design with a cross-sectional approach. The study samples were medical records of young women diagnosed with breast cancer who were treated at Haji Adam Malik General Hospital Medan. The prevalence of breast cancer in young age women in Haji Adam Malik General Hospital Medan in 2013-2017 was 234 patients (15.2%). In this study, the samples that fulfilled the inclusion criteria were 153, with the majority characteristics of patients were 35-39 years old, stage III, histopathological type of invasive carcinoma of no special type, grade II, and clinical subtype of triple-negative. The prevalence of young age breast cancer is lower than old age breast cancer. Young women tend to be diagnosed with breast cancer in advanced stage and intermediate grade with aggressive biological characteristics.

Author Biography

Denny Rifsal Siregar, Faculty Of Medicine, Universitas Sumatera Utara

Department of Surgical Oncology, Haji Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

References

[1] American Cancer Society, “Breast Cancer Facts & Figures 2017-2018,” American Cancer Society, Inc, 2017.
[2] M. Morrow, H.J. Burstein, J.R. Harris, “Malignant Tumors of the Breast,” in Cancer Principle & Practice of Oncology, V.T. DeVita, T.S. Lawrence, S.A. Rosenberg, Eds. Philadelphia: Lippincott Williams & Wilkins, 2015, 1117-1152.
[3] M. Piccart, T. Gathani, D. Zardavas, H.A. Azim Jr, C. Sotiriou, G. Viale, et al, “Cancer of the Breast,” in Oxford Textbook of Oncology, D.J. Kerr, D.G. Haller, C.J. van de Velde, M. Baumann, Eds. United Kingdom: Oxford University Press, 2016, 546-559.
[4] F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre, A. Jemal, “Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA: A Cancer Journal for Clinicians, vol. 68, no. 6, pp. 394-424. 2018.
[5] H. Purwanto, D. Handojo, S.J. Haryono, W.A. Harahap, Eds, Panduan Penatalaksanaan Kanker Payudara. Jakarta: PERABOI, 2015.
[6] J. Ferlay, M. Ervik, F. Lam, M. Colombet, L. Mery, M. Piñeros, et al, “Global Cancer Observatory: Cancer Today,” International Agency for Research on Cancer, 2018 Sep. [Online] Available: https://gco.iarc.fr/today.
[7] H.B. Lee, W. Han, “Unique Features of Young Age Breast Cancer and Its Management,” Journal of Breast Cancer, vol. 17, no.4, pp. 301-307. 2014.
[8] D.S. Eugênio, J.A. Souza, R. Chojniak, A.G. Bitencourt, L. Graziano, E.F. Souza, “Breast cancer features in women under the age of 40 years,” Revista da Associacao Medica Brasileira, vol. 62, no. 8, pp. 755-761. 2016.
[9] M.D. Hartaningsih, W. Sudarsa, “Kanker Payudara pada Usia Muda di Bagian Bedah Onkologi Rumah Sakit Umum Pusat Sanglah Denpasar Tahun 2002-2012,” EUM, vol. 3, no.6. 2014.
[10] P.D. Partini, I.W. Niryana, P.A. Adiputra, “Karakteristik Kanker Payudara Usia Muda di Subbagian Bedah Onkologi Rumah Sakit Umum Pusat Sanglah Tahun 2014-2016,” ISM, vol. 9, no. 1, pp. 76-79. 2018.
[11] Cancer Research UK. “Breast cancer incidence (invasive) statistics,” Cancer Research UK, 2018. [Online] Available: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer/incidence-invasive
[12] I. Mehdi, E.A. Monem, B.J. Bahrani, S.A. Kharusi, A.M. Nada, J.A. Lawati, et al, “Age at diagnosis of female breast cancer in Oman: Issues and implications,” South Asian Journal of Cancer, vol.3, no.2, pp. 101-106. 2014.
[13] S.K. Lee, S.W. Kim, J.H. Yu, J.E. Lee, J.Y. Kim, J. Woo, et al, “Is the high proportion of young age at breast cancer onset a unique feature of Asian breast cancer?,” Breast Cancer Research and Treatment, vol.173, no.1, pp.189-199. 2019.
[14] T.H. Keegan, D.J. Press, L. Tao, M.C. DeRouen, A.W. Kurian, C.A. Clarke, et al, “Impact of breast cancer subtypes on 3-year survival among adolescent and young adult women,” Breast Cancer Research, vol. 15, no. 5, pp. R95. 2013.
[15] C. Villarreal-Garza, A. Mohar, J.E. Bargallo-Rocha, F. Lasa-Gonsebatt, N. Reynoso-Noverón, J. Matus-Santos, et al, “Molecular Subtypes and Prognosis in Young Mexican Women With Breast Cancer,” Clinical Breast Cancer, vol.17, no.3, pp. e95-e102. 2017.
[16] M.C. Cormedi, E.F. Lopes, S. Maistro, R.A. Roela, M.A. Folgueira, “Clinical stage and histological type of the most common carcinomas diagnosed in young adults in a reference cancer hospital,” Clinics (São Paulo), vol.73, suppl 1, pp. e656s. 2018.
[17] J. Bakkach, M. Mansouri, T. Derkaoui, A. Loudiyi, M. Fihri, S. Hassani, et al, “Clinicopathologic and prognostic features of breast cancer in young women: a series from North of Morocco,” BMC Women’s Health, vol.17, no.1, pp.106. 2017.
[18] G.A. Dyanti, N.L. Suariyani, “Faktor-Faktor Keterlambatan Penderita Kanker Payudara dalam Melakukan Pemeriksaan Awal ke Pelayanan Kesehatan,” Kemas, vol.11, no.2, pp. 96-104. 2016.
[19] E.O. Jenkins, A.M. Deal, C.K. Anders, A. Prat, C.M. Perou, L.A. Carey, et al, “Age-Spesific Changes in Intrinsic Breast Cancer Subtypes: A Focus on Older Women,” The Oncologist, vol. 19, no. 10, pp. 1076-1083. 2014.
[20] M. Kolečková, Z. Kolář, J. Ehrmann, G. Kořínková, R. Trojanec, “Age-associated prognostic and predictive biomarkers in patients with breast cancer,” Oncology Letters, vol. 13, no. 6, pp. 4201-4207. 2017.
[21] G. Curigliano, H.J. Burstein, E.P. Winer, M. Gnant, P. Dubsky, S. Loibl, et al, “De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017,” Annals of Oncology, vol. 28, no. 8, pp. 1700-1712. 2017.
[22] H. Alabdulkareem, T. Pinchinat, S. Khan, A. Landers, P. Christos, R. Simmons, et al, “The impact of molecular subtype on breast cancer recurrence in young women treated with contemporary adjuvant therapy,” The Breast Journal, vol. 24, no. 2, pp. 148-153. 2018.

Published

2020-03-30

How to Cite

1.
Siregar DR, Christoper A. PREVALENCE AND CHARACTERISTICS OF BREAST CANCER IN YOUNG WOMEN . Sumat. Med. J. [Internet]. 2020Mar.30 [cited 2020May26];3(2). Available from: https://talenta.usu.ac.id/smj/article/view/2919

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.