Correlation of ACE Gene Polymorphism and Hypertension in Stroke Ischemic Patients
DOI:
https://doi.org/10.32734/sumej.v3i1.3310Keywords:
ACE, gene, Hypertension, Ischemic Stroke, PolymorphismAbstract
Stroke is the third highest cerebrovascular disease in the world with high mortality and disability rate that is mostly dominated by ischemic stroke. Genetic factor that had been reported to have an indirect effect in increasing the incidence of ischemic stroke is ACE gene polymorphism. ACE gene polymorphism is characterized by the insertion marked by letter (I) or deletion marked by letter (D) on intron 16, chromosome 17. ACE gene polymorphism has drawn a lot of attention from scientists and had been reported to have an indirect effect in increasing the ischemic stroke incidence through pathogenesis of hypertension and atherosclerosis. In this study, 78 subjects of ischemic stroke consist of 43 subjects with hypertension and 35 subjects with normotension. I allele of ACE gene polymorphism was more dominant than D allele in hypertensive ischemic stroke patients (72.1% > 27,9%) and this dominance was also seen in the incidence of hypertension vs normotension (55.4% > 44.6%). However, the correlation of ACE gene polymorphism with the incidence of hypertension was not statistically significant when compared based on its genotype (p=0.280) and allele (p=0.948).
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References
P. Parmar et al., “The Stroke Riskometer(TM) App: validation of a data collection tool and stroke risk predictor,†Int. J. Stroke, vol. 10, no. 2, pp. 231–244, Feb. 2015.
D. K. Burns and V. Kumar, “Sistem Saraf,†in Buku Ajar Patologi, 7th ed., V. Kumar, R. S. Cotran, and S. L. Robbins, Eds. Jakarta: EGC, 2013, pp. 908–913.
B. Norrving, D. Leys, M. Brainin, and S. Davis, “Stroke Definition in the ICD-11 at the WHO,†World Neurology Online, 2018. [Online]. Available: https://worldneurologyonline.com/article/stroke-definition-in-the-icd-11-at-the-who/. [Accessed: 29-Mar-2019].
S. R. Martini and T. A. Kent, “Ischemic Stroke,†in Cardiology Secrets, 5th ed., G. N. Levine, Ed. Texas: Elsevier, 2017, pp. 493–503.
T. Indrajaya, “The role of ACE gene polymorphism on pathogenesis of ischemic stroke,†Acta Med. Indones., vol. 43, no. 3, pp. 152–157, 2011.
L. Ljungberg, “Angiotensin-Converting Enzyme for Cardiovascular Diseases,†Linköping University, Sweden, 2009.
F. A. Sayed-Tabatabaei, B. A. Oostra, A. Isaacs, C. M. Van Duijn, and J. C. M. Witteman, “ACE polymorphisms,†Circ. Res., vol. 98, no. 9, pp. 1123–1133, 2006.
B. Rigat, C. Hubert, F. Alhenc-Gelas, P. Cambien, P. Corvol, and F. Soubrier, “An insertion/deletion polymorphism in the angiotensin-1-converting enzyme gene accounting for half the variance of serum enzyme levels.,†J. Clin. Invest., vol. 86, pp. 1343–1364, 1990.
H. Rasyid, S. Bakri, and I. Yusuf, “Angiotensin-converting enzyme gene polymorphisms, blood pressure and pulse pressure in subjects with essential hypertension in a South Sulawesi Indonesian population.,†Acta Med. Indones., vol. 44, no. 4, pp. 280–3, 2012.
M. Hollander, “The Role of Atherosclerosis, Hormones and Genes in Stroke,†J. Trop. Ecol. - J TROP ECOL, 2003.
Genetics Home Reference, “ACE gene,†Natl. Libr. Med., vol. 16, pp. 1–6, 2019.
S. Kamajaya, “Polimorfisme Gen Angiotensin I Converting Enzyme (ACE) Insersi/Delesi (I/D) dan Hipertensi pada Penduduk Mlati Sleman,†Universitas Gadjah Mada, Yogyakarta, Indonesia, 2011.
R. Pratiwi, “Polimorfisme Gen Angiotensin I Converting Enzyme (ACE) Insersi/Delesi (I/D) pada Penderita Hipertensi dan Prehipertensi di Mlati Kabupaten Sleman Yogyakarta,†Universitas Gadjah Mada, Yogyakarta, Indonesia, 2011.
S. Shaleh, “Hubungan Polimorfisme Gen ACE dengan Hipertensi pada Pasien Stroke Iskemik,†Skripsi Univ. Gadjah Mada, 2017.
C. A. Arina, D. Amir, Y. Siregar, and R. J. Sembiring, “The Role of Polymorphism Gen Methylene Tetra Hydrofolate Reductase (MTHFR) C677T in Ischaemic Stroke Patients with and Without Hypertension,†Open Access Maced. J. Med. Sci., vol. 7, no. 1, pp. 29–32, 2019.
F. Heidari et al., “Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene among Malay male hypertensive infjects in response to ACE inhibitors,†JRAAS - J. Renin-Angiotensin-Aldosterone Syst., vol. 16, no. 4, pp. 872–879, 2015.
Q. He et al., “Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population,†PLoS One, vol. 8, no. 10, pp. 1–9, 2013.
S. A. Syed, “ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population,†Cardiol. Res., vol. 1, no. 1, pp. 1–7, 2010.
L. Ljungberg et al., “The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: A cross-sectional study,†JRAAS - J. Renin-Angiotensin-Aldosterone Syst., vol. 12, no. 3, pp. 281–289, 2011.
R. G. Malueka, E. K. Dwianingsih, S. Sutarni, A. Gofir, and I. Setyopranoto, “Association between ace gene polymorphism and functional outcome of ischemic stroke,†J. Neurol. Sci., vol. 381, p. 618, 2017.
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