Association between Serum Alp Levels and Pre- Operative LDH towards Clinical Prognosis of Osteosarcoma Patients in H. Adam Malik Hospital, Medan
DOI:
https://doi.org/10.32734/sumej.v6i1.8991Keywords:
ALP, LDH, prognosis, osteosarcomaAbstract
Background: Osteosarcoma remains a challenging disease, especially for young patients, due to its tendency to spread to the lungs and resist treatment. Identifying reliable markers at diagnosis could help doctors start more effective treatment earlier and improve patient outcomes. Two blood markers, ALP and LDH, may offer insight into a patient’s prognosis. Objective: This study explored whether pre-surgery levels of ALP and LDH could predict survival in osteosarcoma patients. Methods: Researchers reviewed medical records of patients diagnosed with osteosarcoma at RSUP Haji Adam Malik Medan from 2015 to 2017. This retrospective study included those who met the necessary criteria and had complete data. Results: The study found no strong evidence linking ALP or LDH levels to five-year survival. ALP had a very weak negative correlation with survival (r = -0.019), while LDH showed a weak positive correlation (r = 0.093). Median ALP was 212 U/L; LDH was 489 U/L. Sensitivity and specificity were moderate for both markers. Conclusion: There is no significant relationship between ALP and LDH with five-year survival.
Downloads
References
Beaury MW, Kelly ML, Sharp G, Cottrell JA. A review of osteosarcoma therapeutics. J Cancer Treat Diagn. 2018.
Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y. Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer Med. 2018;7(12):6124–36. Available from: https://doi.org/10.1002/cam4.1820.
Bhatti Z, Kiran K, Shoaib M, Nisa SU, Arif A. Alkaline phosphatase as serum tumor marker in osteosarcoma. Pak J Med Health Sci. 2022;16(3):30–3. Available from: https://doi.org/10.53350/pjmhs2216330.
Chen J, Sun MX, Hua YQ, Cai ZD. Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: A meta-analysis. J Cancer Res Clin Oncol. 2014;140(7):1205–10. Available from: https://doi.org/10.1007/s00432-014-1644-0.
Deng T, Zhang J, Meng Y, Zhou Y, Li W. Higher pretreatment lactate dehydrogenase concentration predicts worse overall survival in patients with lung cancer. Medicine (Baltimore). 2018;97(36). Available from: https://doi.org/10.1097/MD.0000000000012524.
Baptista AM, Zumárraga JP, dos Santos RPN, Haubert GO, de Camargo OP. Serum values of alkaline phosphatase and lactate dehydrogenase in Ewing’s Sarcoma. Acta Ortop Bras. 2016;24(4):196–9. Available from: https://doi.org/10.1590/1413-785220162404161312.
Baseesee HH, AlSabri I, Aldujele AB, Allebban Z. Prognostic markers in osteosarcoma patients in the Najaf Province of Iraq. J Clin Exp Oncol. 2018;7(2). Available from: https://doi.org/10.4172/2324-9110.1000215.
Fan XL, Cai GP, Zhu LL, Ding GM. Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: A meta-analysis. Drug Des Devel Ther. 2015;9:5925–32. Available from: https://doi.org/10.2147/DDDT.S91217.
Fu Y, Lan T, Cai H, Lu A, Yu W. Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma. Medicine (Baltimore). 2018;97(19). Available from: https://doi.org/10.1097/MD.0000000000010741.
Gan J, Wang W, Yang Z, Pan J, Zheng L, Yin L. Prognostic value of pretreatment serum lactate dehydrogenase level in pancreatic cancer patients: A meta-analysis of 18 observational studies. Medicine (Baltimore). 2018;97(48). Available from: https://doi.org/10.1097/MD.0000000000013151.
Gok Durnali A, Paksoy Turkoz F, Ardic Yukruk F, Tokluoglu S, Yazici OK, Demirci A, et al. Outcomes of adolescent and adult patients with lung metastatic osteosarcoma and comparison of synchronous and metachronous lung metastatic groups. PLoS One. 2016;11(5). Available from: https://doi.org/10.1371/journal.pone.0152621.
Hou XM, Yuan SQ, Zhao D, Liu XJ, Wu XA. LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma. Biosci Rep. 2019;39(1). Available from: https://doi.org/10.1042/BSR20181476.
González-Billalabeitia E, Hitt R, Fernández J, Conde E, Martínez-Tello F, de Salamanca RE, et al. Pre-treatment serum lactate dehydrogenase level is an important prognostic factor in high-grade extremity osteosarcoma. Clin Transl Oncol. 2009;11(7):479–83. Available from: https://doi.org/10.1007/s12094-009-0388-9.
Gu R, Sun Y. Does serum alkaline phosphatase level really indicate the prognosis in patients with osteosarcoma? A meta-analysis. J Cancer Res Ther. 2018;14(9):S468–72. Available from: https://doi.org/10.4103/0973-1482.177217.
Hao H, Chen L, Huang D, Ge J, Qiu Y, Hao L. Meta-analysis of alkaline phosphatase and prognosis for osteosarcoma. Eur J Cancer Care (Engl). 2017;26(5). Available from: https://doi.org/10.1111/ecc.12536.
Forkasiewicz A, Dorociak M, Stach K, Szelachowski P, Tabola R, Augoff K. The usefulness of lactate dehydrogenase measurements in current oncological practice. Cell Mol Biol Lett. 2020;25(1). Available from: https://doi.org/10.1186/s11658-020-00228-7.
Friebele JC, Peck J, Pan X, Abdel-Rasoul M, Mayerson JL. Osteosarcoma: A meta-analysis and review of the literature. Am J Orthop. 2015. Available from: http://www.amjorthopedics.com.
Yao Z, Tan Z, Yang J, Yang Y, Wang C, Chen J, et al. Prognostic nomogram for predicting 5-year overall survival in Chinese patients with high-grade osteosarcoma. Sci Rep. 2021;11(1). doi:10.1038/s41598-021-97090-0
Fu Y, Lan T, Cai H, Lu A, Yu W. Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma. Medicine (Baltimore). 2018;97(19). Available from: https://doi.org/10.1097/MD.0000000000010741.
Hirayama T, Kusunoki S, Saeki H, Onagi H, Yamaguchi M, Fujino K, et al. Serum alkaline phosphatase is useful to diagnose and predict the prognosis of osteosarcoma arising from uterus: A case report. J Gynecol Surg. 2020;36(4):205–8. Available from: https://doi.org/10.1089/gyn.2019.0143.
Kamal A, Prasetyo R. Association between laboratory markers and oncological outcomes in patients with osteosarcoma: A review of osteosarcoma treatment in Indonesia. Formosan J Surg. 2018;51(3):111–7. Available from: https://doi.org/10.4103/fjs.fjs_140_17.
Kamal AF, Abubakar I, Salamah T. Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma: A cross sectional study. Ann Med Surg. 2021;64. Available from: https://doi.org/10.1016/j.amsu.2021.102228.
Bacci G, Longhi A, Ferrari S, Briccoli A, Donati D, de Paolis M, et al. Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: Experience at Rizzoli on 1421 patients treated over the last 30 years. Tumori. 2004;90(5):478–84. Available from: https://doi.org/10.1177/030089160409000507.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Sumatera Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Sumatera Medical Journal (SUMEJ) and Faculty of Medicine as well as TALENTA Publisher Universitas Sumatera Utara as publisher of the journal.
Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, will be allowed only with a written permission from Sumatera Medical Journal (SUMEJ).
The Copyright Transfer Form can be downloaded here.
The copyright form should be signed originally and sent to the Editorial Office in the form of original mail or scanned document.
