PENGARUH PEMBERIAN KOMBINASI SEL PUNCA PULPA GIGI DAN RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 TERHADAP KADAR FOSFATASE ALKALI PADA PULPA GIGI TIKUS TERINFLAMASI

COMBINATION OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN- 2 AND DENTAL PULP STEM CELLS ENHANCED EXPESSION OF ALKALINE PHOSPHATASE ON INFLAMED RAT’S PULP

Authors

  • Endang W Bachtiar Departemen Biologi Oral Fakultas Kedokteran Gigi, Universitas Indonesia, Indonesia
  • Mindya Yuniastuty Departemen Biologi Oral Fakultas Kedokteran Gigi, Universitas Indonesia, Indonesia
  • Aimee Monica Departemen Biologi Oral Fakultas Kedokteran Gigi, Universitas Indonesia, Indonesia
  • Boy M Bachtiar Departemen Biologi Oral Fakultas Kedokteran Gigi, Universitas Indonesia, Indonesia

DOI:

https://doi.org/10.32734/dentika.v16i1.1897

Keywords:

bone morphogenetic protein- 2, alkaline phosphatase, pulp regeneration, dental pulp stem cells

Abstract

Pulp irritation will form reparative dentin as a defense mechanism. Currently, the materials used to help the defense pulp
still have many shortcomings. Therefore, the effect of dental pulp stem cells (DPSC) and rhBMP- 2 combination on
alkaline phosphatase (ALP) expresion in rat ’s dental pulp was analyzed in this research. Lipopolysaccharide was used to
irritate the pulp of 12 Sprague-Dawley rats. Materials were then applied to each group and ALP expression was
performed on the first and second week. The result showed that in the first week, giving a combination of pulp stem cells
with recombinant BMP-2 had not been visible to increase expression of alkaline phosphatase (ALP), a biomarker
regeneration of pulp, but the increase in ALP expression occurred in the second week. In conclusion, a combination of
pulp stem cells and rhBMP-2 can increase the expression of ALP on inflamed rat’s pulp.

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Published

2011-07-06

How to Cite

Endang W Bachtiar, Mindya Yuniastuty, Aimee Monica, & Boy M Bachtiar. (2011). PENGARUH PEMBERIAN KOMBINASI SEL PUNCA PULPA GIGI DAN RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 TERHADAP KADAR FOSFATASE ALKALI PADA PULPA GIGI TIKUS TERINFLAMASI: COMBINATION OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN- 2 AND DENTAL PULP STEM CELLS ENHANCED EXPESSION OF ALKALINE PHOSPHATASE ON INFLAMED RAT’S PULP. Dentika: Dental Journal, 16(1), 36-40. https://doi.org/10.32734/dentika.v16i1.1897

Issue

Vol. 16 No. 1 (2011): Dentika Dental Journal

Section

Articles