EKSPRESI INTERLEUKIN -1 ALFA (IL-1α) PADA HIPERSENSITIF KONTAK AKIBAT TONGUE PIERCING

INTERLEUKIN - 1 ALFA EXPRESSION IN CONTACT HIPERSENSITIVITY CAUSED BY TONGUE PIERCING

Abstract

Tongue piercing is increasingly used by teenagers lately. Studies have reported the tongue piercing's side effects on oral
health such as poor oral hygiene, too th and periodontal destruction and taste bud destruction. Tongue piercing may cause
hypersensitivity which may be caused by the components of tongue piercing. Interleukin (IL)-1α expression may increase
in sensitization and elicitation phase of contact hypersensitivity. The aim of this study was to know the IL-1α expression
induced b y tongue piercing. This study used fifteen two-months year old male Wistar rat (Rattus norvegicus) which was
divided into two group, control group treated by vaseline (I) and treatment group. Treatment group divided into three
groups, named tongue piercing treatment until sensitization phase (IIA), elicitation phase for 24 hours (IIB), and 48 hours
(IIC). Inteleukin- 1α expression using immunohistochemistry (IHC) staining from tissue specimen was taken from the
tongue. The result of this study showed that IL- 1α expression in sensitization phase was higher than elicitation phase and
was a significant difference of IL-1α expression between sensitization and elicitation phase (p<0,05). LSD test result
showed there was a significant difference between sensitization phase and 24 hours elicitation phase, between
sensitization phase and 48 hours elicitation phase. In conclusion, there was a difference of IL-1α expression between
sensitization and elicitation phase of contact hypersensitivity induced by tongue piercing.