IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies

Authors

  • Muhammad Rusda Universitas Sumatera Utara
  • Riza Rivany Universitas Sumatera Utara
  • Citra Lestari Hasibuan Universitas Sumatera Utara
  • Delfi Lutan Universitas Sumatera Utara
  • Dudy Aldiansyah Universitas Sumatera Utara
  • Cut Adeya Adella Universitas Sumatera Utara

DOI:

https://doi.org/10.32734/sumej.v2i1.719

Keywords:

Normal Ovaries, Benign Ovarian Cysts, Ovarian Cancer, MMP7, VEGF

Abstract

To investigate the association of MMP7 and VEGF expression with ovarian cancer, benign ovarian cysts, and normal ovaries. This study was analytical research with case-control design. In the study, IHC expression of MMP7 and VEGF was carried out on paraffin block of ovarian cancer tissue, benign ovarian cyst, and normal ovary. In 40 subjects with ovarian tumors, 17 patients were found with positive MMP7 expression. In the control group, no subjects were found with positive MMP7 expression. There was a significant relationship between MMP7 expression and ovarian tumor incidence. Meanwhile, in 40 subjects with ovarian tumors, 21 patients were found with positive VEGF expression. In the control group, no subjects with positive VEGF expression were found. There was a significant relationship between VEGF expression and ovarian tumor incidence. There was a significant relationship between MMP7 and VEGF expression with ovarian tumor incidence.

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Author Biographies

Muhammad Rusda, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Riza Rivany, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Citra Lestari Hasibuan, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Delfi Lutan, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Dudy Aldiansyah, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Cut Adeya Adella, Universitas Sumatera Utara

Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sumatera Utara

Published

2019-01-30

How to Cite

1.
Rusda M, Rivany R, Hasibuan CL, Lutan D, Aldiansyah D, Adella CA. IHC Expression Relationships MMP7 and VEGF With Normal Ovaries and Ovarian Pathologies. Sumat. Med. J. [Internet]. 2019Jan.30 [cited 2020Jul.13];2(1):47 - 54. Available from: https://talenta.usu.ac.id/smj/article/view/719

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